1,3-Dimethylurea Chemical Properties

Melting point:

101-104 °C(lit.)

Boiling point:

268-270 °C(lit.)

Density 

1.142

vapor pressure 

6 hPa (115 °C)

refractive index 

1.4715 (estimate)

Flash point:

157 °C

storage temp. 

Store below +30°C.

solubility 

H₂O: 0.1 g/mL, clear, colorless

pka

14.57±0.46(Predicted)

form 

Crystals

color 

White

PH

9.0-9.5 (100g/l, H2O, 20℃)

Water Solubility 

765 g/L (21.5 ºC)

BRN 

1740672

InChIKey

MGJKQDOBUOMPEZ-UHFFFAOYSA-N

LogP

-0.783 at 25℃

CAS DataBase Reference

96-31-1(CAS DataBase Reference)

NIST Chemistry Reference

Urea, N,N'-dimethyl-(96-31-1)

EPA Substance Registry System

1,3-Dimethylurea (96-31-1)

Safety Information

Risk Statements 

62-63-68

Safety Statements 

22-24/25

WGK Germany 

1

RTECS 

YS9868000

F 

10-21

Autoignition Temperature

400 °C

TSCA 

Yes

HS Code 

29241900

Hazardous Substances Data

96-31-1(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 4000 mg/kg

MSDS

• Language:English Provider:1,3-Dimethylurea
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1,3-Dimethylurea Usage And Synthesis

Description

1, 3-Dimethylurea is a urea derivative and used as an intermediate in organic synthesis. It is a colorless crystalline powder with little toxicity. It is also used for synthesis of caffeine, pharmachemicals, textile aids, herbicides and other. In the textile processing industry 1,3-dimethylurea is used as intermediate for the production of formaldehyde-free easy-care finishing agents for textiles. In the Swiss Product Register there are 38 products containing 1,3-dimethylurea, among them 17 products intended for consumer use. Product types are e.g. paints and cleaning agents. The content of 1,3-dimethylurea in consumer products is up to 10 % (Swiss Product Register, 2003). Use in cosmetics has been proposed, but there is no information available as to its actual use in such applications.

Chemical Properties

white crystals

Uses

N,N′-Dimethylurea can be used:

• As a starting material to synthesize N,N′-dimethyl-6-amino uracil.
• In combination with β-cyclodextrin derivatives, to form low melting mixtures (LMMs), which can be used as solvents for hydroformylation and Tsuji-Trost reactions.
• To synthesize N,N′-disubstituted-4-aryl-3,4-dihydropyrimidinones via Biginelli condensation under solvent-free conditions.

Definition

ChEBI: A member of the class of ureas that is urea substituted by methyl groups at positions 1 and 3.

General Description

Colorless crystals.

Air & Water Reactions

Water soluble.

Reactivity Profile

1,3-Dimethylurea is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 1,3-Dimethylurea emits toxic fumes.

Fire Hazard

Flash point data for 1,3-Dimethylurea are not available; 1,3-Dimethylurea is probably combustible.

Safety Profile

Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx

Purification Methods

Crystallise the urea from acetone/diethyl ether by cooling in an ice bath. Also crystallise it from EtOH and dry it at 50o/5mm for 24hours [Bloemendahl & Somsen J Am Chem Soc 107 3426 1985]. [Beilstein 4 IV 207.]

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