XMD17 109
XMD17 109 Basic information
- Product Name:
- XMD17 109
- Synonyms:
-
- XMD17 109;XMD17109
- CS-1288
- XMD17 109
- XMD17-109
- 11-Cyclopentyl-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dihydro-5-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
- 11-Cyclopentyl-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dihydro-5-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one XMD17-109
- 6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 11-cyclopentyl-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dihydro-5-methyl-
- 11-Cyclopentyl-2-[2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5-methylpyrimido[4,5-b][1,4]benzodiazepin-6-one
- CAS:
- 1435488-37-1
- MF:
- C36H46N8O3
- MW:
- 638.8
- EINECS:
- 604-604-1
- Product Categories:
-
- Inhibitors
- MAPK
- Mol File:
- 1435488-37-1.mol
XMD17 109 Chemical Properties
- storage temp.
- -20°C
- solubility
- ≥31.95 mg/mL in DMSO; insoluble in H2O; ≥86.6 mg/mL in EtOH
- form
- powder
- color
- white to beige
XMD17 109 Usage And Synthesis
Uses
ERK5-IN-1 is a potent selective ERK5 inhibitor, inhibiting EGFR-induced ERK5 autophosphorylation and ERK5 enzymatic activity. Orally bioavailable.
Biological Activity
xmd17-109 is a new inhibitor of erk5, ic50 value in hela cell is 0.09 ± 0.03 μm, and in vitro, enzymatic ic50 value is 0.162 ± 0.006 μm.xmd17-109 is capable of inhibiting the erk5 autophosphorylation in cells.[1]through intravenous injection and oral delivery of xmd17-109 in mice, the pharmacokinetic properties of this compound are as bellows: the t1/2 (half time) is 8.2 h, the plasma clearance is 8.64 ml/min/kg (data of intravenous injection), the auc (area under the curve) of oral delivery is 15745 h*ng/ml and the oral bioavailability is 90%.
storage
Store at -20°C
References
1. deng, x., et al., structural determinants for erk5 (mapk7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11h)-ones. european journal of medicinal chemistry, 2013. 70: p. 758-767.
XMD17 109Supplier
- Tel
- sales@boylechem.com
- Tel
- 21-57721279
- sales@shydchem.com.cn
- Tel
- 025-83697070
- info@chemlin.com.cn
- Tel
- 021-58950125
- info@chemexpress.com
- Tel
- +86-21-38682181 15900741819
XMD17 109(1435488-37-1)Related Product Information
- 6H-PyriMido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino]-5,11-diMethyl-
- XMD17-51
- XMD16-5
- ACK1-B19
- XMD-17-51 Trifluoroacetate
- 2-[[2-Ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one