4-methoxy-3-methylaniline Chemical Properties

Melting point:

57-60℃

Boiling point:

252.03°C (rough estimate)

Density 

1.0630 (rough estimate)

refractive index 

1.5360 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

5.32±0.10(Predicted)

color 

Dark Red to Black

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36/37/39

WGK Germany 

3

HS Code 

2922290090

4-methoxy-3-methylaniline Usage And Synthesis

Uses

4-Methoxy-3-methylaniline is used in preparation of triamine pyrimidine derivatives as antitumor agents.

Synthesis

The synthesis of 4-methoxy-3-methylaniline is as follows:
4-Methoxy-3-methyl-phenylamine10% Palladium on carbon (10% Pd/C) (1.5 g) was added to a solution of 1 -methoxy-2- methyl-4-nitrobenzene (9.5 g, 57 mmol) in methanol (100 ml_). The mixture was stirred under a hydrogen atmosphere (1 atm.) at room temperature for 16 h. The mixture was filtered through a pad of CELITE and the filtrate was evaporated in vacuo to yield 4- methoxy-3-methylphenylamine (8.0 g, 57 mmol, 100%).

4-methoxy-3-methylaniline(136-90-3)Related Product Information

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