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(+/-)-EvodiaMine

Basic information Safety Supplier Related

(+/-)-EvodiaMine Basic information

Product Name:
(+/-)-EvodiaMine
Synonyms:
  • TXDUTHBFYKGSAH-UHFFFAOYSA-N
  • (+/-)-Evodiamine>
  • (+/-)-Evodiamine
  • 14-Methyl-7,8,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(13H)-one
  • 14-Methyl-7,8,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(13H)-one
CAS:
518-18-3
MF:
C19H17N3O
MW:
303.36
Mol File:
518-18-3.mol
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(+/-)-EvodiaMine Chemical Properties

Melting point:
272°C(lit.)
Boiling point:
575.1±50.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
0-10°C
solubility 
very slightly in Acetone
form 
powder to crystal
pka
17.27±0.20(Predicted)
color 
White to Orange to Green
λmax
268nm(EtOH)(lit.)
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Safety Information

HS Code 
2939.80.0000
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(+/-)-EvodiaMine Usage And Synthesis

Description

Evodiamine is extracted and isolated from the fruit of Evodiarutaecarpa (Juss.) Benth., a rutaceae plant. It is converted into Isoevodiamine after being boiled with hydrochloric acid alcohol solution.

Definition

ChEBI: LSM-6483 is a member of beta-carbolines.

Pharmacokinetics

1. Antitumor activity
Evodiamine can inhibit the proliferation of various tumor cells, including cervical cancer, colon cancer, lung cancer, melanoma, T lymphocyte-like leukemia, prostate cancer Inhibition of proliferation of various tumor cells including cancer and breast cancer.
2. Anti-senile dementia effect

3. Effects on endocrine system
Evodiamine can inhibit 3β-hydroxysteroid dehydrogenase by reducing the activity of intracellular cyclic adenosine monophosphate (cAMP) related pathways (3β-HSD) and other steroid hormone production-related enzymes, reduce and affect the expression of signal transduction and RNA activation protein (StAR), and directly act on rat adrenal cortex reticulum cells to inhibit the secretion of corticosterone.
4. Weight loss and hypoglycemic effect
5.Anti-inflammatory and analgesic effect

6. Effects on the cardiovascular system

(+/-)-EvodiaMineSupplier

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