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R-afatinib

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R-afatinib Basic information

Product Name:
R-afatinib
Synonyms:
  • 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-
  • (R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetra- hydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino) but-2-enamide
  • (R,E)-N-(4-((3-Chloro-4- fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinozolin- 6-yl)-4-(dimethylamino)but-2-enamide
  • Afatinib impurity 3/R-afatinib/(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
  • Afatinib-2
  • Afatinib Enantiomer
  • (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
  • 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-
CAS:
945553-91-3
MF:
C24H25ClFN5O3
MW:
485.94
Mol File:
945553-91-3.mol
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R-afatinib Chemical Properties

Boiling point:
676.9±55.0 °C(Predicted)
Density 
1.380±0.06 g/cm3(Predicted)
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
11.79±0.43(Predicted)
color 
Pale Beige to Pale Brown
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R-afatinib Usage And Synthesis

Uses

(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, is an impurity of Afatinib (A355300) an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

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