1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Chemical Properties

Melting point:

56-58 °C(lit.)

Boiling point:

65-66 °C8 mm Hg(lit.)

Density 

1.1850 (estimate)

Flash point:

65-66°C/8mm

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

pka

10.17±0.18(Predicted)

color 

White to Gray to Brown

Water Solubility 

Soluble 0.68 G/L

BRN 

2359087

CAS DataBase Reference

394-32-1(CAS DataBase Reference)

NIST Chemistry Reference

5-Fluoro-2-hydroxyacetophenone(394-32-1)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-37/39-36/37/39

WGK Germany 

3

RTECS 

AM8502300

HazardClass 

IRRITANT

HS Code 

29147000

MSDS

• Language:English Provider:1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Usage And Synthesis

Chemical Properties

light yellow to beige-brown crystals 

Uses

5′-Fluoro-2′-hydroxyacetophenone has been used in the preparation of:

• 1-(5-fluoro-2-hydroxyphenyl)-3-hydroxy-5-phenyl-2,4-pentadien-1-one
• 3-hydroxy and 3-methoxyflavones
• 3-hydroxy and 3-methoxy 2-styrylchromones

Definition

ChEBI: 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one is an aromatic ketone.

Preparation

Preparation by Fries rearrangement of 4-fluorophenyl acetate with aluminium chloride without solvent between 115° and 150° (88–89%).

General Description

5-fluoro-2-hydroxy acetophenone, also known as 2-ethanoyl-4-fluorophenol or 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone, is a kind of important medicine intermediate, can be used as multiple beta-blockers synthetic intermediate, has vast market prospect.

Synthesis

The preparation method of 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone under following steps:
Performing double esterification on amino groups and phenolic hydroxy in one step by taking amino-phenol as a raw material.
Performing Fries rearrangement under the condition of aluminum chloride/sodium chloride.
Heating a hydrolyzate after completing fluorine diazotization to obtain finished 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone.

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone(394-32-1)Related Product Information

• 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
• 6-Fluoro-4-chromanone
• 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE
• 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE
• 2'-FLUORO-6'-HYDROXYACETOPHENONE
• 1-(3-FLUORO-4-HYDROXYPHENYL)-1-ETHANONE
• 4'-Fluoro-2'-hydroxyacetophenone
• 1-(2-FLUORO-4-HYDROXYPHENYL)-1-ETHANONE
• 2'-Hydroxyacetophenone
• 4-Fluorophenol
• 6-FLUORO-2-METHYL-4-CHROMANONE
• 6-FLUORO-3-FORMYLCHROMONE
• 6-FLUORO-2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID
• METHYL 7-FLUORO-2-(METHOXYMETHYL)-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE
• 7-FLUORO-2-METHYL-5-OXO-N-[3-(TRIFLUOROMETHYL)PHENYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE
• (E)-3-(4-CHLOROBENZYLIDENE)-6-FLUORO-2,3-DIHYDROCHROMEN-4-ONE
• N-(4-CHLOROPHENYL)-7-FLUORO-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE
• 6-FLUORO-2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID METHYL ESTER