Basic information Safety Supplier Related

Carboxyatractyloside

Basic information Safety Supplier Related

Carboxyatractyloside Basic information

Product Name:
Carboxyatractyloside
Synonyms:
  • (2beta,15alpha)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioic acid
  • Carboxyatractyloside tripotassium salt
  • Kaur-16-ene-18,19-dioic acid, 15-hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-β-D-glucopyranosyl]oxy]-, (2β,15α)-
  • Carboxyatractylosidetripotassiumsal
  • Kaur-16-ene-18,19-dioic acid, 15-hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-β-D-glucopyranosyl]oxy]-, (2β,15α)-
CAS:
77228-71-8
MF:
C31H46O18S2
MW:
770.81
Product Categories:
  • reagent
  • standard substance
  • chemical reagent
  • herbal extract
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
Mol File:
77228-71-8.mol
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Carboxyatractyloside Chemical Properties

Density 
1.58±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
H2O: ≥10mg/mL
pka
-3?+-.0.18(Predicted)
form 
solid
color 
white
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Safety Information

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
36/37-45
RIDADR 
UN 2811 6.1 / PGI
WGK Germany 
3
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Carboxyatractyloside Usage And Synthesis

Uses

Carboxyatractyloside potassium salt has been used as an activator of Ca2+-induced mPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) opening. It has also been used as a adenine nucleotide translocator (ANT) inhibitor to study the inhibition of oxidative phosphorylation in intact T98G glioma cells.

Biochem/physiol Actions

Carboxyatractyloside is a highly selective inhibitor of cytosolic side-specific mitochondrial ADP/ATP carrier; i.e. adenine nucleotide translocase (ANT); causes stabilization of the c conformation of ANT leading to permeability transition pore (PTP) opening, loss of mitochondrial membrane potential, and apoptosis.

target

Calcium Channel | P450 (e.g. CYP17)

CarboxyatractylosideSupplier

ShangHai YuanYe Biotechnology Co., Ltd.
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Shanghai Tauto Biotech Co., Ltd.
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TargetMol Chemicals Inc.
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Cheng Du Pufeide Biotechnology Co., Ltd.
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028-82610909 13388174823
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