Carboxyatractyloside
Carboxyatractyloside Basic information
- Product Name:
- Carboxyatractyloside
- Synonyms:
-
- (2beta,15alpha)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioic acid
- Carboxyatractyloside tripotassium salt
- Kaur-16-ene-18,19-dioic acid, 15-hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-β-D-glucopyranosyl]oxy]-, (2β,15α)-
- Carboxyatractylosidetripotassiumsal
- Carboxyatractyloside, 10 mM in DMSO
- Carboxyatractyloside potassium salt - Bio-X ?
- CAS:
- 77228-71-8
- MF:
- C31H46O18S2
- MW:
- 770.81
- Product Categories:
-
- reagent
- standard substance
- chemical reagent
- herbal extract
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- Mol File:
- 77228-71-8.mol
Carboxyatractyloside Chemical Properties
- Density
- 1.58±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- H2O: ≥10mg/mL
- pka
- -3?+-.0.18(Predicted)
- form
- solid
- color
- white
- biological source
- Xanthium sibiricum
- optical activity
- [α]/D -34 to -48°, c =0.5 in water
- Water Solubility
- H2O: ≥10mg/mL
Carboxyatractyloside Usage And Synthesis
Chemical Properties
White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Atractylodes lancea.
Uses
Carboxyatractyloside potassium salt has been used as an activator of Ca2+-induced mPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) opening. It has also been used as a adenine nucleotide translocator (ANT) inhibitor to study the inhibition of oxidative phosphorylation in intact T98G glioma cells.
Biochem/physiol Actions
Carboxyatractyloside is a highly selective inhibitor of cytosolic side-specific mitochondrial ADP/ATP carrier; i.e. adenine nucleotide translocase (ANT); causes stabilization of the c conformation of ANT leading to permeability transition pore (PTP) opening, loss of mitochondrial membrane potential, and apoptosis.
target
Calcium Channel | P450 (e.g. CYP17)
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Carboxyatractyloside(77228-71-8)Related Product Information
- 3-Dimethylamino-1-propanol
- Acetoin
- Cupric acetate monohydrate
- Madecassoside
- ATRACTYLOSIDE POTASSIUM SALT
- ALLEOSIDE A
- Terrestrosin D
- xanthatin
- Xanthiside
- roburic acid
- Poricoic acid A(F)
- Pachymic acid
- 1,3,5-Tricaffeoylquinic acid
- Terrestrosin K
- Madecassic acid
- dipotassium dihydrogen 15alpha-hydroxy-2beta-[[2-O-isovaleryl-3,4-di-O-sulphonato-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioate