DiMethyl bicyclo[1.1.1]pentane-1,3-dicarboxylate Chemical Properties

Boiling point:

233.8±20.0 °C(Predicted)

Density 

1.369±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

Appearance

White to off-white Solid

Safety Information

HS Code 

2917200090

DiMethyl bicyclo[1.1.1]pentane-1,3-dicarboxylate Usage And Synthesis

Uses

Dimethyl Bicyclo[1.1.1]pentane-1,3-dicarboxylate is a useful reagent for preparation of terminally functionalized [n]staffanes.

Synthesis

The crude product of compound 6 obtained in the previous step was directly dissolved in methanol (200 mL) and heated to reflux for 4 hours. After completion of the reaction, the reaction solution was concentrated to obtain the crude product of compound 7. Crystallization and purification was carried out by petroleum ether to finally obtain the pure compound 7 (12.2 g) in 90% yield.

References

[1] Journal of Medicinal Chemistry, 1996, vol. 39, # 15, p. 2874 - 2876
[2] Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 2, p. 221 - 227
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3414 - 3424
[4] Patent: CN105294442, 2016, A. Location in patent: Paragraph 0006; 0014

DiMethyl bicyclo[1.1.1]pentane-1,3-dicarboxylate(115913-32-1)Related Product Information

• bicyclo[3.2.1]octane-2,4-dione
• Bicyclo[1.1.0]butane-1-carboxylic acid, sodium salt (1:1)
• bicyclo[2.1.1]hexane-4-carboxylic acid
• Potassium Bicyclo[2.2.1]heptan-2-yltrifluoroborate
• Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid
• bicyclo[1.1.1]pentan-1-ylmethanamine hydrochloride
• 5-Norbornene-2,3-dicarboxylic acid
• bicyclo[2.2.2]octane-1-carboxylic acid
• tert-Butyl 5-norbornene-2-carboxylate
• BICYCLO[3.3.1]NONANE-2,6-DIONE
• Bicyclo[1.1.1]pentane-1-carboxylic acid
• 2-NORBORNEN-2-YLBORONIC ACID
• bicyclo[1.1.1]pentan-1-ylmethanol
• Bicyclo[2.2.2]octane-1,4-dimethanol
• 5-Norbornene-2-methanol
• Bicyclo[2.2.1]heptane-2,5-dione
• DiMethyl bicyclo[2.2.1]heptane-1,4-carboxylate
• dimethyl (3aR,6aS)-hexahydrocyclopenta[c]pyrrole-2,5(1H)-dicarboxylate