Basic information Description In vitro In vivo Safety Supplier Related

Y320

Basic information Description In vitro In vivo Safety Supplier Related

Y320 Basic information

Product Name:
Y320
Synonyms:
  • Y320
  • 1-(4-CHLOROPHENYL)-N-(3-CYANO-4-(4-MORPHOLINOPIPERIDIN-1-YL)PHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE
  • 1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide
  • 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-car
  • 1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide Y320
  • Y320 1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide
  • Y-320, >=98%
  • 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxami
CAS:
288250-47-5
MF:
C27H29ClN6O2
MW:
505.01
EINECS:
200-256-5
Product Categories:
  • Inhibitors
Mol File:
288250-47-5.mol
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Y320 Chemical Properties

Boiling point:
631.2±55.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
≥24.8 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
form 
solid
pka
11.82±0.70(Predicted)
color 
Off-white to pink
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Y320 Usage And Synthesis

Description

Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.

In vitro

Y-320 also inhibits the production of IFN-γ and TNF-α by mouse CD4 T cells stimulated with IL-15, CXCL12, and anti-CD3 mAb.

In vivo

Y-320 (0.3-3 mg/kg p.o.) ameliorates collagen-induced arthritis (CIA) in Mice with a reduction of IL-17 mRNA in arthritic joints, and also shows therapeutic effects on CIA in cynomolgus monkeys. Moreover, Y-320 shows a synergistic effect in combination with anti-TNF-α mAb on chronic-progressing CIA in mice.

Uses

1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide inhibits T cell activation induced by IL-15 and shows a therapeutic effect on collagen-induced arthritis in DBA/1J mice.

Biological Activity

y-320 is a new phenylpyrazoleanilide immunomodulator [1].immunotherapy refers to treatment of disease by suppressing, inducing or enhancing an immune response.y-320 is a new phenylpyrazoleanilide immunomodulator. y-320 inhibited il-17 production by cd4 t cells induced by il-15 with ic50 values of 20-60 nm [1].in type ii collagen-induced arthritis (cia) mice, oral administration of y-320 (0.3-3 mg/kg) reduced il-17 mrna expression and significantly inhibited the development of joint destruction and arthritis. the combination of y-320 with anti-murine tumor necrosis factor-α (tnf-α) monoclonal antibody exhibited a synergistic effect. in cynomolgus monkeys, y-320 (0.3-1 mg/kg) relieved cia. these results suggested that y-320 could be a useful candidate for therapy of rheumatoid arthritis (ra) [1].

References

[1]. ushio h, ishibuchi s, oshita k, et al. a new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. pharmaceuticals (basel), 2013, 7(1): 1-17.

Y320Supplier

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
Tel
21-57721279
Email
sales@shydchem.com.cn
Products Intro
Product Name:1-(4-chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide
CAS:288250-47-5
Purity:97% Package:1g,5g,10g,100g,1kg
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Email
cfzhang@aikonchem.com
Products Intro
Product Name:Y-320
CAS:288250-47-5
Purity:95% Package:1g;5g;10g
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Email
info@chemexpress.com
Products Intro
Product Name:Y-320
CAS:288250-47-5
Purity:>98% Package:930RMB/5mg
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Email
Sales-JP@TCIchemicals.com
Products Intro
Product Name:Y-320
CAS:288250-47-5
Purity:95-98% Package:5 mg,25 mg
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
Products Intro
Product Name:Y-320
CAS:288250-47-5
Purity:>98% Package:930RMB/5mg