APIGENIN-7-GLUCURONIDE Chemical Properties

Melting point:

>300℃

Boiling point:

841.8±65.0 °C(Predicted)

Density 

1.737

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMSO : 65 mg/mL (145.62 mM; Need ultrasonic)

form 

powder

pka

2.73±0.70(Predicted)

color 

Yellowish

InChIKey

JBFOLLJCGUCDQP-ZFORQUDYSA-N

SMILES

C12C=C(C(O)=CC=1C(=O)C=C(C1=CC=C(O)C=C1)O2)O[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](C(=O)O)O1)O |&1:20,21,23,24,26,r|

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

APIGENIN-7-GLUCURONIDE Usage And Synthesis

Chemical Properties

Yellow powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Scutellaria barbata, Erigeron breviscapus, and Erigeron chinensis.

Uses

Apigenin 7-Glucuronide is a metabolite of Apigenin, which induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological differentiation. Apigenin has also been reported to enhance the gap juntion intracellular communication in liver cells.

Definition

ChEBI: Apigenin 7-glucuronide is a member of flavonoids and a glucosiduronic acid.

target

NO | PGE | TNF-α | NOS | COX | AP-1 | ERK | p38MAPK | MMP-3 | MMP-8 | MMP-9 | MMP-13

IC 50

MMP-3: 12.87 μM (IC₅₀); MMP-8: 22.39 μM (IC₅₀); MMP-9: 17.52 μM (IC₅₀); MMP13: 0.27 μM (IC₅₀)

APIGENIN-7-GLUCURONIDE(29741-09-1)Related Product Information

• 5-[(β-D-Glucopyranosyl)oxy]-4',7-dihydroxyflavone
• apigenin 7-O-(6-O-malonylglucoside)
• hydroxygenkwanin
• 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one
• Naringenin 7-O-β-D-Glucuronide (Mixture of Diastereomers)
• 4',5-DIHYDROXY-7-METHOXYFLAVONE
• Naringenin
• PONCIRIN
• Apigenin 7-glucoside
• APIIN
• Apigenin 7-O-(2G-rhaMnosyl)gentiobioside
• Apigenin
• 6-beta-D-Glucopyranosyl-8-beta-D-xylopyranosylapigenin
• Apigenin 6-C-α-L-arabinopyranosyl-8-C-β-D-xylopyranoside
• Scutellarin
• APIGENIN-7-GLUCURONIDE
• FLAVONE
• Apigenin-D5