Di-tert-butyl disulfide Chemical Properties

Melting point:

-5 °C

Boiling point:

200-201 °C(lit.)

Density 

0.923 g/mL at 25 °C(lit.)

vapor density 

5 (vs air)

vapor pressure 

51.7 mm Hg ( 37.7 °C)

refractive index 

n20/D 1.490(lit.)

Flash point:

144 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Sparingly), Ethanol (Slightly)

form 

Liquid

color 

Clear pale yellow to yellow

explosive limit

0.8%(V)

Odor Threshold

0.0018ppm

BRN 

1698170

InChIKey

BKCNDTDWDGQHSD-UHFFFAOYSA-N

LogP

4.698 (est)

CAS DataBase Reference

110-06-5(CAS DataBase Reference)

EPA Substance Registry System

Disulfide, bis(1,1-dimethylethyl) (110-06-5)

Safety Information

Hazard Codes 

N

Risk Statements 

51/53-43-36/37/38

Safety Statements 

61-37/39-26-24

RIDADR 

UN 3082 9/PG 3

WGK Germany 

2

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29309090

Toxicity

LD50 orally in Rabbit: 6200 mg/kg LD50 dermal Rabbit > 2000 mg/kg

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

Di-tert-butyl disulfide Usage And Synthesis

Description

Di-tert-butyl disulfide is one of the important organic intermediates.It is an important raw material for the synthesis of disulfide bond-containing sulfinyl and oxythio compounds. It can be used as a vulcanizing agent for rubber and elastomers in industry. It is also a monomer for the synthesis of proteins and other biologically active molecules.

Chemical Properties

clear pale yellow to yellow liquid

Uses

Di-tert-butyl disulfide is used in the preparation of gold-supported thin film from symmetrical and mixed disulphide adsorbates.
Mechanism of the oxidation of di-tert-butyl disulfide in the presence of H2O2 catalyzed by bis(acetylacetonato)oxovanadium and a chiral Schiff-base ligand has been investigated.
Di-tert-butyl disulfide has been used in the preparation of gold-supported thin film from symmetrical and mixed disulphide adsorbates.

Uses

Di-tert-Butyl Disulfide is a general reagent used in the synthesis of a novel neuropeptide Y (NPY) Y5 receptor antagonist Velneperit) used in the treatment of obesity.

Synthesis Reference(s)

Synthetic Communications, 13, p. 611, 1983 DOI: 10.1080/00397918308059536
Synthesis, p. 669, 1978 DOI: 10.1055/s-1978-24844
Tetrahedron Letters, 31, p. 3591, 1990 DOI: 10.1016/S0040-4039(00)94450-2

General Description

Mechanism of the oxidation of di-tert-butyl disulfide in the presence of H₂O₂ catalyzed by bis(acetylacetonato)oxovanadium and a chiral Schiff-base ligand has been investigated.

Di-tert-butyl disulfide(110-06-5)Related Product Information

• tert-Butylsulfinyl chloride
• tert-Butyllithium
• tert-Butanesulfinamide
• Butyl disulfide
• DI-TERT-DODECYL DISULFIDE
• (R)-tert-Butanethiosulfinate
• Di-tert-butyl disulfide
• D-PENICILLAMINE DISULFIDE
• DI-TERT-OCTYL DISULFIDE
• (S)-(-)-TERT-BUTYL TERT-BUTANETHIOSULFINATE
• (D-PEN2,PEN5)-ENKEPHALIN
• (D-PEN2,P-CHLORO-PHE4,D-PEN5)-ENKEPHALIN
• D-PEN-GLY-PHE-PEN
• D-PEN-GLY-PHE-D-PEN
• DI-TERT-AMYL DISULFIDE
• N1-(2-([1,1-DIMETHYL-2-(OCTADECYLIMINO)ETHYL]DITHIO)-2-METHYLPROPYLIDENE)OCTADECAN-1-AMINE
• AP-SS
• N1-(2-([1,1-DIMETHYL-2-(OCTADECYLAMINO)ETHYL]DITHIO)-2-METHYLPROPYL)OCTADECAN-1-AMINE