N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide Chemical Properties

Boiling point:

741.3±60.0 °C(Predicted)

Density 

1.381±0.06 g/cm3(Predicted)

pka

14.01±0.20(Predicted)

form 

Solid

color 

Light yellow to yellow

N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide Usage And Synthesis

Uses

(Rac)-Apremilast ((Rac)-CC-10004) is the racemic mixture of Apremilast. (Rac)-Apremilast has anti-inflammatory properties and can be used for research on inflammatory diseases, such as psoriasis[1][2].

IC 50

hPDE4D: 0.3 nM (IC₅₀)

References

[1] Armstrong AW, et al. Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: Efficacy and safety results from the 52-week, randomized, double-blinded, placebo-controlled phase 3 POETYK PSO-1 trial. J Am Acad Dermatol. 2023 Jan;88(1):29-39. DOI:10.1016/j.jaad.2022.07.002
[2] Man H W, et al. Discovery of (S)-N-{2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1, 3-dioxo-2, 3-dihydro-1 H-isoindol-4-yl} acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-α inhibitor[J]. Journal of medicinal chemistry, 2009, 52(6): 1522-1524.

N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide(253168-86-4)Related Product Information

• Apremilast Impurity 84
• 3-Ethoxy-4-methoxy benzonitrile
• 3-Nitrophthalic acid
• Apremilast Impurity 19
• Apremilast Impurity 15
• Apremilast impurity 18
• 1H-Isoindole-1,3(2H)-dione, 2-[1-(3-ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethyl]-
• 4-acetamidophthalic acid
• 1-Methyl-3-nitrophthalate
• 4-Nitrophthalic acid
• Apremilast Impurity 4
• BenzeneMethanaMine, 4-ethoxy-3-Methoxy-a-[(Methylsulfonyl)Methyl]-
• Apremilast-d8
• Apremilast Impurity 25
• 1-(3,4-Diethoxyphenyl)-2-(methylsulfonyl)ethan-1-amine
• Apremilast Impurity 28
• (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
• Apremilast Impurity 34