LL-Z-1640-2 Chemical Properties

storage temp. 

Desiccate at -20°C

solubility 

Soluble in DMSO

form 

White solid

color 

white

InChI

1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3

InChIKey

NEQZWEXWOFPKOT-UHFFFAOYSA-N

SMILES

O1C(CC=CC(=O)C(C(CC=Cc2c(c(cc(c2)OC)O)C1=O)O)O)C

Safety Information

Hazard Codes 

Xi

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

LL-Z-1640-2 Usage And Synthesis

Uses

LL Z1640-2 is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.

Biological Activity

Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor- β -activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC 50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF- κ B (IC 50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF- α -induced apoptosis in vitro .

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