LL-Z-1640-2
LL-Z-1640-2 Basic information
- Product Name:
- LL-Z-1640-2
- Synonyms:
-
- (3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
- (5Z)-7-Oxozeaenol
- JNK/p38 inhibitor
- C292, L 783278
- LL-Z-1640-2
- (5Z)-7-Oxozeaenol (5Z-7-oxozeaenol)
- 5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione
- CAS:
- 66018-38-0
- MF:
- C19H22O7
- MW:
- 362.37
- Product Categories:
-
- antibiotic
- Mol File:
- 66018-38-0.mol
LL-Z-1640-2 Chemical Properties
- storage temp.
- Desiccate at -20°C
- solubility
- Soluble in DMSO
- form
- White solid
Safety Information
- Hazard Codes
- Xi
LL-Z-1640-2 Usage And Synthesis
Uses
LL Z1640-2 is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.
Biological Activity
Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor- β -activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC 50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF- κ B (IC 50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF- α -induced apoptosis in vitro .
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