ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Metabolism > AhR modulators > UM729
UM729
UM729 Basic information
- Product Name:
- UM729
- Synonyms:
-
- UM729
- C07
- methyl 4-(3-(piperidin-1-yl)propylamino)-9H-pyrimido[4,5-b]indole-7-carboxylate
- 4-[[3-(1-Piperidinyl)propyl]amino]-9H-pyrimido[4,5-b]indole-7-carboxylic acid methyl ester
- CS-1240
- UM-729;UM 729
- 9H-Pyrimido[4,5-b]indole-7-carboxylic acid, 4-[[3-(1-piperidinyl)propyl]amino]-, methyl ester
- UM729 USP/EP/BP
- CAS:
- 1448723-60-1
- MF:
- C20H25N5O2
- MW:
- 367.44
- Product Categories:
-
- Inhibitors
- Mol File:
- 1448723-60-1.mol
More
Less
UM729 Usage And Synthesis
Biological Activity
UM729 is an enhancer of aryl hydrocarbon receptor (AhR) antagonists.
in vitro
um729 expands normal hematopoietic stem and progenitor cells (HSPC) in an AhR-independent manner, and UM729 inhibits AML cell differentiation. In 05H163 cells, the addition of UM729 increased CD34+CD15- Number of cells. It can inhibit the differentiation of most AML cells in combination with AhR antagonists.
in vivo
In NSG mice, UM729, alone or in combination with SR1, enhanced engraftment but not leukemia stem cell (LSC) frequency distribution.
UM729Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
LETOPHARM LIMITED
- Tel
- +86-21-5821 5861
- sales@letopharm.com
SPIRO PHARMA
- Tel
- eric_feng1954@126.com
Target molecule Corp.
- Tel
- 857-239-0968
- service1@targetmol.com
Shanghai Rechem science Co., Ltd.
- Tel
- 21-31433387 15618786686
- sales@rechemscience.com