5'-Guanylic acid Chemical Properties

Melting point:

220 - 223°C

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO (Very Slightly, Heated, Sonicated), Water (Slightly, Sonicated)

form 

Solid

Boiling point:

64 °C(Press: 0.05 Torr)

Density 

2.47±0.1 g/cm3(Predicted)

pka

1.86±0.10(Predicted)

color 

White to Off-White

Odor

at 100.00?%. odorless

Cosmetics Ingredients Functions

HUMECTANT
SKIN CONDITIONING
SKIN CONDITIONING - EMOLLIENT

InChI

1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)

InChIKey

RQFCJASXJCIDSX-UHFFFAOYSA-N

SMILES

O=C(NC(N)=N1)C2=C1N(C=N2)C3C(O)C(C(COP(O)(O)=O)O3)O

LogP

-2.000

CAS DataBase Reference

85-32-5(CAS DataBase Reference)

EPA Substance Registry System

5'-Guanylic acid (85-32-5)

Safety Information

WGK Germany 

WGK 3

TSCA 

TSCA listed

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

Toxicity

LDLo intraperitoneal in mouse: 1500mg/kg

MSDS

• Language:English Provider:[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

5'-Guanylic acid Usage And Synthesis

Uses

Biochemical research, flavor potentiator (disodium salt).5-Guanylic Acid is a useful reagent for the chemo- and site-specific reductive amination of N2-guanine oligonucleotides.

Definition

The monophosphoric ester of guanine, i.e., the nucleotide containing guanine, d-ribose, and phosphoric acid. The phosphate may be esterified to either the 2, 3, or 5 carbon of ribose, yielding guanosine-2′-phosphate, guanosine-3′-phosphate, and guanosine-

Synthesis

Under low-temperature conditions, guanosine reacts with a phosphorylating agent (e.g., phosphorus oxychloride POCl3) in an organic solvent (e.g., trimethyl phosphate) to generate the intermediate dichlorophosphate. Subsequently, this intermediate is hydrolyzed in the presence of water or ice to convert into a monophosphate, thereby yielding the target product, 5'-Guanylic acid.

Purification Methods

Crystallise it from water and dry it at 110o. [Beilstein 26 III/IV 3910.]

5'-Guanylic acid(85-32-5)Related Product Information

• ALTRENOGEST
• Zinc phosphate
• Guanosine 5'-monophosphate disodium salt
• Ethyl 2-(Chlorosulfonyl)acetate
• Guanosine
• Guanine
• NUCLEOSIDE PHOSPHORYLASE BACTERIAL
• Glycyrrhizic acid
• Acyclovir
• Glycine
• Creatine phosphate
• 6-Thioguanine
• L-DIHYDROOROTIC ACID
• FERRIC PHOSPHATE
• Trisodium phosphate
• 8-AZAGUANINE
• Calcium phosphate
• 2-Amino-6-chloropurine Riboside