CX6258(HCL) CAS#: 1353859-00-3

CX6258(HCL)

Basic information Safety Supplier Related

Product Name:

CX6258(HCL)

Synonyms:

CX6258(HCL)
(3E)-5-chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-Indol-2-one, hydrochloride (1:1)
CX6258(HCL) 2H-Indol-2-one, 5-chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-, hydro
CX-6258 Hydrochloride
CX6285
Pim-Kinase Inhibitor X
CX6258(HCL) USP/EP/BP
(E)-5-Chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one hydrochloride

CAS:

1353859-00-3

MF:

C26H25Cl2N3O3

MW:

498.4

Product Categories:

Mol File:

1353859-00-3.mol

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storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO:57.0(Max Conc. mg/mL);114.37(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);2.01(Max Conc. mM)
form: Solid
color: Orange to red

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CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor.

CX-6258 (50-100 mg/kg; p.o; daily; over a period of 21 days) exhibits robust in vivo efficacy in two Pim kinases driven tumor models^[1].

Animal Model:	Nude mice, MV-4-11 xenograft models^[1]
Dosage:	50 mg/kg, 100 mg/kg.
Administration:	Oral administration; once daily; over a period of 21 days.
Result:	Exhibitd dose dependent efficacy, with a 50 mg/kg dose producing 45% tumor growth inhibition (TGI) and a 100 mg/kg dose producing 75% TGI.

Dalian Meilun Biotech Co., Ltd.

AdooQ BioScience, LLC

Sichuan Wei Keqi Biological Technology Co., Ltd.

Shanghai EFE Biological Technology Co., Ltd.

Shanghai YuanYe Biotechnology Co., Ltd.

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