1-(2-ETHOXY-2-OXOETHYL)PYRIDINIUM BROMIDE Chemical Properties

Melting point:

137-139°C

storage temp. 

Inert atmosphere,Room Temperature

Appearance

White to off-white Solid

Safety Information

HazardClass 

IRRITANT

Toxicity

mouse,LDLo,subcutaneous,370mg/kg (370mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 35, Pg. 75, 1929.

1-(2-ETHOXY-2-OXOETHYL)PYRIDINIUM BROMIDE Usage And Synthesis

Synthesis

Example 3: Synthesis of compounds shown in chemical formula 11 According to reaction scheme 3, the steps for the synthesis of the compound shown in chemical formula 11 are as follows: Step 1: Synthesis of intermediate G 105.0 g (628.4 mmol) of ethyl bromoacetate and 994.67 g (12.6 mol) of pyridine were suspended in an appropriate amount of solvent. The suspension was stirred and reacted at room temperature for 2 hours. Upon completion of the reaction, 1,000 mL of diethyl ether was added to the reaction mixture to induce precipitation of the product. The precipitated pale yellow solid was separated by filtration and washed with diethyl ether. After drying, 152.3 g of Intermediate G was obtained in 98% yield.

References

[1] Patent: US2012/313091, 2012, A1. Location in patent: Page/Page column 69-70
[2] Journal of the American Chemical Society, 1981, vol. 103, # 11, p. 3233 - 3235
[3] European Journal of Organic Chemistry, 2015, vol. 2015, # 13, p. 2889 - 2901
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981, p. 1180 - 1185
[5] Journal of Materials Chemistry, 1999, vol. 9, # 9, p. 2183 - 2188

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