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3-Deschloro-4-Desfluoro-4-Chloro-3-Fluorogefitinib

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3-Deschloro-4-Desfluoro-4-Chloro-3-Fluorogefitinib Basic information

Product Name:
3-Deschloro-4-Desfluoro-4-Chloro-3-Fluorogefitinib
Synonyms:
  • 3-Deschloro-4-Desfluoro-4-Chloro-3-Fluorogefitinib
  • Desfluoro Gefitinib
  • Gefitinib EP impurity B
  • N-(4-Chloro-3-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine
  • Gefitinib Impurity 16
  • Gefitinib Impurity HCl (3-Deschloro-4-Desfluoro-4-Chloro-3-Fluoro Gefitinib HCl)
  • 4-Quinazolinamine, N-(4-chloro-3-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-
  • Gefitinib Impurity HCl
CAS:
1603814-04-5
MF:
C22H24ClFN4O3
MW:
446.9
Mol File:
1603814-04-5.mol
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3-Deschloro-4-Desfluoro-4-Chloro-3-Fluorogefitinib Chemical Properties

Melting point:
180-183oC
Boiling point:
585.0±50.0 °C(Predicted)
Density 
1.322±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
7.00±0.10(Predicted)
color 
Off-White to Light Brown
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3-Deschloro-4-Desfluoro-4-Chloro-3-Fluorogefitinib Usage And Synthesis

Uses

3-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib is an impurity of Gefitinib (G304000); a tyrosine kinase inhibitor that targets the epidermal growth factor receptor (EGFR).

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