ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Cytoskeletal Signaling > Microtubule Associated inhibitors > TAI-1
TAI-1
TAI-1 Basic information
- Product Name:
- TAI-1
- Synonyms:
-
- N-(4-(4-(4-methoxyphenoxy)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide
- TAI 1;TAI1
- 4-Pyridinecarboxamide, N-[4-[4-(4-methoxyphenoxy)-2,6-dimethylphenyl]-2-thiazolyl]-
- TAI-1 USP/EP/BP
- TAI 1,TAI1,inhibit,Inhibitor,Apoptosis,TAI-1
- TAI-1, 10 mM in DMSO
- CAS:
- 1334921-03-7
- MF:
- C24H21N3O3S
- MW:
- 431.51
- Product Categories:
-
- Inhibitors
- Mol File:
- 1334921-03-7.mol
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TAI-1 Chemical Properties
- Density
- 1.281±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥43.2 mg/mL in DMSO; insoluble in H2O; ≥3.17 mg/mL in EtOH
- form
- solid
- pka
- 5.38±0.70(Predicted)
- color
- White to off-white
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TAI-1 Usage And Synthesis
Uses
TAI-1, an orally active anticancer agent, is a highly potent first-in-class Hec1 inhibitor, with a GI50 of 13.48 nM in K562 cells[1].
in vivo
TAI-1 (20 mg/kg intravenously IV/ or 150 mg/kg per oral PO/BID) inhibits tumor growth in multiple cancer xenograft models[1].
| Animal Model: | C.B-17 SCID mice (6-7 weeks, 21-24 g)[1]. |
| Dosage: | 20 mg/kg intravenously IV/ or 150 mg/kg per oral PO/BID. |
| Administration: | QDx28 cycles. |
| Result: | Led to significant tumor growth retardation in Huh-7 and modest tumor inhibition was noted tor the Colo205 and MDA-MB-231 models. Did not lead to any loss in body weight. |
IC 50
NEK2
References
[1] Lynn Y L Huang, et al. Characterization of the Biological Activity of a Potent Small Molecule Hec1 Inhibitor TAI-1. J Exp Clin Cancer Res. 2014 Jan 9;33(1):6. DOI:10.1186/1756-9966-33-6
TAI-1Supplier
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Hangzhou ChangCun Biotechnology Co., Ltd.
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- 0571-; 13567100326
- 158848739@qq.com
Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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Target molecule Corp.
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- 857-239-0968
- service1@targetmol.com
ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
- 2853530910@QQ.com