3'-Demethylnobiletin Chemical Properties

Melting point:

170-171 °C

Boiling point:

613.8±55.0 °C(Predicted)

Density 

1.304±0.06 g/cm3(Predicted)

pka

9.95±0.10(Predicted)

form 

Solid

color 

Off-white to light yellow

3'-Demethylnobiletin Usage And Synthesis

Uses

3'-Demethylnobiletin, a derivative of Nobiletin, is a polymethoxyflavonoid in citrus fruits[1]. Nobiletin exhibits anticancer activity and inhibits tumor angiogenesis by regulating Src, FAK, and STAT3 signaling[2].

Definition

ChEBI: 3'-Hydroxy-4',5,6,7,8-pentamethoxyflavone is a member of flavonoids and an ether.

References

[1] Murakami A, et al. In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits. Biosci Biotechnol Biochem. 2001 Jan;65(1):194-7. DOI:10.1271/bbb.65.194
[2] Sp N, et al. Nobiletin Inhibits Angiogenesis by Regulating Src/FAK/STAT3-Mediated Signaling through PXN in ER+ Breast Cancer Cells. Int J Mol Sci. 2017 Apr 30;18(5). pii: E935. DOI:10.3390/ijms18050935

3'-Demethylnobiletin(112448-39-2)Related Product Information

• Hesperetin
• 14,15-beta-dihydroxyklaineanone
• 5-DEMETHYLNOBILETIN
• 3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-one
• MERANZIN
• 3,3',4',5,6,7,8-heptamethoxyflavone
• 25R-Inokosterone
• Neohesperidin
• Nobiletin
• Poricoic acid A(F)
• 27-DEOXYACTEIN
• Hesperidin
• 13-alpha-(21)-Epoxyeurycomanone
• 25S-Inokosterone
• AURAPTENE
• (-)-8-[(S)-2,3-Dihydroxy-3-methylbutyl]-7-methoxy-2H-1-benzopyran-2-one
• EUDESMINE