6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride Chemical Properties

Boiling point:

478.7±40.0 °C(Predicted)

Density 

1.047±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

H2O: soluble25mg/mL, clear

form 

powder

pka

10.57±0.10(Predicted)

color 

white to beige

Water Solubility 

Water: 25 mg/mL，clear

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

46

WGK Germany 

3

6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride Usage And Synthesis

Uses

ENMD-1068 hydrochloride has been used as a protease-activated receptor 2 (PAR2) antagonist to determine the pathway responsible for paw edema induced by Crotalus durissus terrificus venom serine protease (Cdtsp 2).

Biochem/physiol Actions

ENMD-1068 is an antagonist of protease-activated receptor 2 (PAR2). The compound blocks TNFα production in synovial explants from patients with arthritis, and inhibits mast cell tryptase-induced recruitment of eosinophils into the pleural cavity of mice.

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