5-(3,5-difluorobenzyl)-1H-indazol-3-amine Chemical Properties

Boiling point:

450.7±40.0 °C(Predicted)

Density 

1.399±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

pka

14.82±0.40(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C14H11F2N3/c15-10-4-9(5-11(16)7-10)3-8-1-2-13-12(6-8)14(17)19-18-13/h1-2,4-7H,3H2,(H3,17,18,19)

InChIKey

CZQCRNRCCQSJHD-UHFFFAOYSA-N

SMILES

N1C2=C(C=C(CC3=CC(F)=CC(F)=C3)C=C2)C(N)=N1

Safety Information

HS Code 

2933998090

5-(3,5-difluorobenzyl)-1H-indazol-3-amine Usage And Synthesis

Uses

5-(3,5-difluorobenzyl)-1H-indazol-3-amine is an intermediates of Entrectinib(RXDX-101). Entrectinib (RXDX-101, NMS-E628) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Entrectinib (RXDX-101) induces autophagy.