LORMETAZEPAM
LORMETAZEPAM Basic information
- Product Name:
- LORMETAZEPAM
- Synonyms:
-
- 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-
- 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-
- 2h-1,4-benzodiazepin-2-one,1,3-dihydro-7-chloro-5-(o-chlorophenyl)-3-hydroxy-1
- 2h-1,4-benzodiazepin-2-one,7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy
- 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
- 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1h-1,4-benzodiaze
- 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
- 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one
- CAS:
- 848-75-9
- MF:
- C16H12Cl2N2O2
- MW:
- 335.18
- EINECS:
- 212-700-5
- Product Categories:
-
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 848-75-9.mol
LORMETAZEPAM Chemical Properties
- Melting point:
- 163-168°C
- Boiling point:
- 575.8±50.0 °C(Predicted)
- Density
- 1.4463 (rough estimate)
- refractive index
- 1.6100 (estimate)
- Flash point:
- 9℃
- storage temp.
- Controlled Substance, -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 11.60±0.40(Predicted)
- color
- Pale Yellow to Pale Green
Safety Information
- Hazard Codes
- F,T
- Risk Statements
- 11-23/24/25-39/23/24/25-22
- Safety Statements
- 7-16-36/37-45-36
- RIDADR
- 3249
- WGK Germany
- 1
- HazardClass
- 6.1(b)
- PackingGroup
- III
LORMETAZEPAM Usage And Synthesis
Chemical Properties
Pale Green Solid
Originator
Loramet ,Wyeth, W. Germany,1980
Uses
An analog of Lorazepam (L469850). Sedative, hypnotic. Controlled substance (depressant).
Definition
ChEBI: Lormetazepam is a 1,4-benzodiazepinone compound having a methyl substituent at the 1-position, a hydroxy substituent at the 3-position, a 2-chlorophenyl group at the 5-position and a chloro substituent at the 7-position. It has a role as a sedative. It is a 1,4-benzodiazepinone and an organochlorine compound.
Manufacturing Process
To a suspension of 3.4 g of 3-acetoxy-7-chloro-1,3-dihydro-5-(ochlorophenyl)-2H-1,4-benzodiazepin-2-one in 80 ml of alcohol was added 6 ml of 4 N sodium hydroxide. After complete solution had taken place a solid precipitated that redissolved upon the addition of 80 ml of water. The solution was acidified with acetic acid to give white crystals. After recrystallization from alcohol the compound melted at 192°C to 194°C.
Therapeutic Function
Hypnotic
LORMETAZEPAM(848-75-9)Related Product Information
- MEDAZEPAM
- Benzophenone imine
- OXAZEPAM
- 4-CHLORO-O-TOLUIDINE HYDROCHLORIDE
- 2-(O-TOLYLAMINO)ETHANOL
- Nordazepam
- Lorazepam
- LORMETAZEPAM
- Diazapam
- 1,3-Dihydro-5-(2-chlorophenyl)-2H-1,4-benzodiozepin-2-one
- Delorazepam
- 1,3-Dihydro-5-phenyl-1,4-benzodiazepin-2-one
- TEMAZEPAM
- 2-HYDROXY-N-METHYL-N-PHENYL-ACETAMIDE
- 4-CHLORO-N-METHYLFORMANILIDE
- 1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE
- BENZHYDRYLIDENE METHYLAMINE
- (R)-Lormetazepam