DECANOYL M-NITROANILINE Chemical Properties

Melting point:

72-72.5 °C

Boiling point:

456.4±28.0 °C(Predicted)

Density 

1.097±0.06 g/cm3(Predicted)

solubility 

DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.6 mg/ml; Ethanol: 20 mg/ml

form 

A crystalline solid

pka

14.14±0.70(Predicted)

DECANOYL M-NITROANILINE Usage And Synthesis

Description

Decanoyl m-Nitroaniline (DemNA) is one of several nitroaniline fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity. FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its endogenous substrate anandamide (arachidonyl ethanolamide; AEA). It also will hydrolyze fatty acid amides with fewer carbons and fewer double bonds than arachidonate. Exposure of DemNA to FAAH activity results in the release of the yellow colorimetric dye m-nitroaniline (ε = 13,500 at 410 nm) This allows the fast and convenient measurement of FAAH activity using a 96 well plate spectrophotometer.

Uses

Decanoyl m-Nitroaniline (DemNA) is a nitroaniline fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity (Ab = 410 nm).

References

[1] Micha? Biernacki, et al. Redox system and phospholipid metabolism in the kidney of hypertensive rats after FAAH inhibitor URB597 administration. Redox Biol. 2018 May:15:41-50.

DECANOYL M-NITROANILINE(72298-61-4)Related Product Information

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