2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- Chemical Properties

Melting point:

233.5°C

Boiling point:

411.43°C (rough estimate)

Density 

1.2576 (rough estimate)

refractive index 

1.6081 (estimate)

storage temp. 

Refrigerator

solubility 

DMSO (Slightly)

form 

Solid

color 

White

2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- Usage And Synthesis

Chemical Properties

White or almost white or light beige crystal or crystalline powder, odorless, slightly bitter taste. Soluble in hot water, insoluble in water or ethanol. Melting point 233-234℃(decomposition), melting point 237-239℃. (+)-configuration (Dexrazoxane): [24584-09-6]. Crystallized from aqueous methanol-ether, melting point 193 °C. [α]D+11.35° (C=5, dimethylformamide). Solubility (mg/ml): 10-12 (water), 35-43 (0.1 mol/L hydrochloric acid), 25-34 (0.1 mol/L sodium hydroxide), 6.7-10 (10% ethanol), 1 (methanol), 7.1-10 [water-dimethylformamide (1:1)], 9.7-14.5 [0.1 mol/L citrate buffer (Ph 4) ], 8.7 to 13 [0.1 mol/L boric acid buffer (Ph 9)].

Uses

Razoxane is an inhibitor of Topo II.

Definition

ChEBI: Razoxane is a N-alkylpiperazine.

Safety Profile

Suspected carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: nausea, thrombocytopenia, leukopenia. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-(21416-87-5)Related Product Information

• Dexrazoxane
• Pemetrexed Disodium
• (S)-(-)-1,2-Diaminopropane dihydrochloride
• Dexrazoxane hydrochloride
• 4-(2-AMINO-ETHYL)-PIPERAZIN-2-ONE
• 1,1'-ethylenedipiperazine
• 4,4-(2,3-BUTANEDIYL)-BIS(2,6-PIPERAZINEDIONE)
• ETHYLIMINUM
• 4-methylpiperazine-2,6-dione
• 1-(2-DIETHYLAMINOETHYL)PIPERAZINE
• 2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-
• Piperazine-2,6-dione