2-Amino-5-bromopyrimidine Chemical Properties

Melting point:

241-243 °C (lit.)

Boiling point:

340.7±34.0 °C(Predicted)

Density 

1.844±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

form 

Crystalline Powder, Crystals or Flakes

pka

1.93±0.10(Predicted)

color 

White to light beige

Water Solubility 

Insoluble

InChIKey

UHRHPPKWXSNZLR-UHFFFAOYSA-N

CAS DataBase Reference

7752-82-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,N,Xi

Risk Statements 

22-36-50/53

Safety Statements 

26-60-61

RIDADR 

UN 3077 9/PG 3

WGK Germany 

3

Hazard Note 

Harmful

HazardClass 

IRRITANT, IRRITANT-HARMFUL

PackingGroup 

III

HS Code 

29335995

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

2-Amino-5-bromopyrimidine Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

2-Amino-5-bromopyrimidine was employed:

• in synthesis of pyridine, pyrimidine and pyridinone C-nucleoside phosphoramidites
• in synthesis of 2-phthalimido-5-bromopyrimidine
• as intermediate for the preparation of sulfanilamides and amino acids containing the pyrimidine ring system. The products are potential antiviral agents

General Description

Crystal structure of 2-amino-5-bromopyrimidine was studied.

Synthesis

The synthesis of 2-Amino-5-bromopyrimidine is as follows:The 2-aminopyrimidine (2.5g, 26.29mmol) was dissolved in acetonitrile (25mL) was added N- bromosuccinimide (4.6g, 27.9mmol) under ice-cooling, stirred in the dark overnight at room temperature. Recovery of the solvent under reduced pressure, washed with water (100 mL) was washed, filtered off with suction, and dried in vacuo to give a white solid. Yield: 97%.

storage

Store in cool, well ventilated area. Keep container tightly closed. Light sensitive. Store under argon.

2-Amino-5-bromopyrimidine(7752-82-1)Related Product Information

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