(4-BROMO-2-FORMYLPHENOXY)ACETIC ACID Chemical Properties

Boiling point:

413.6±30.0 °C(Predicted)

Density 

1.699±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

2.96±0.10(Predicted)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

HazardClass 

IRRITANT

(4-BROMO-2-FORMYLPHENOXY)ACETIC ACID Usage And Synthesis

Synthesis

Ethyl (4-bromo-2-formylphenoxy)acetate (60 g, 0.209 mol) was added to a mixture of LiOH (7.5 g, 0.31 mol), THF (250 mL) and water (100 mL) and stirred for 24 h at room temperature. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the residue was acidified to pH=2 with 1.5 N HCl. The resulting solid precipitate was filtered and dried to afford (4-bromo-2-formylphenoxy)acetic acid (50 g, 94% yield).

References

[1] Patent: WO2004/7491, 2004, A1. Location in patent: Page 51
[2] Organic Letters, 2015, vol. 17, # 23, p. 5824 - 5827
[3] European Journal of Medicinal Chemistry, 1999, vol. 34, # 12, p. 1061 - 1070

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