2-HYDROXYACETOPHENONE Chemical Properties

Melting point:

86-89 °C (lit.)

Boiling point:

126 °C / 12mmHg

Density 

1.0963

refractive index 

1.5470 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

13.09±0.10(Predicted)

form 

Powder

color 

Slightly yellow to orange

Water Solubility 

Soluble in water, ether, ethanol, chloroform.

Sensitive 

Air & Moisture Sensitive

LogP

0.721 (est)

CAS DataBase Reference

582-24-1(CAS DataBase Reference)

NIST Chemistry Reference

«alpha»-Hydroxyacetophenone(582-24-1)

EPA Substance Registry System

Ethanone, 2-hydroxy-1-phenyl- (582-24-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

TSCA 

Yes

HS Code 

29144000

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-HYDROXYACETOPHENONE Usage And Synthesis

Chemical Properties

slightly yellow to orange powder

Uses

2-Hydroxyacetophenone can be used to produce 2-hydroxy-1-phenyl-ethanone-(1)-oxime by heating. It is used as pharmaceutical intermediate.

Uses

2-Hydroxyacetophenone can be used as a starting material for the synthesis of:

• Enantioselective 1R-phenyl-1,2-ethanediol in the presence of a rhodium(III) catalyst by asymmetric transfer hydrogenation.
• Copper(II) complexes of 2-hydroxyacetophenone N-substituted thiosemicarbazones.
• Chromium, molybdenum, and ruthenium complexes of 2-hydroxyacetophenone Schiff bases.
• 2-Hydroxyacetophenone-aroyl hydrazone derivatives for inhibition of copper corrosion in nitric acid.

Definition

ChEBI: 2-hydroxyacetophenone is a monohydroxyacetophenone that is acetophenone in which one of the methyl hydrogens has been replaced by a hydroxy group. It is a primary alcohol, a primary alpha-hydroxy ketone and a monohydroxyacetophenone.

2-HYDROXYACETOPHENONE(582-24-1)Related Product Information

• 2'-Hydroxyacetophenone
• 2-Hydroxy-1,4-naphoquinone
• Myricetin
• LAPACHOL
• MORIN
• Rutin
• ANISOIN
• 3-HYDROXYFLAVONE
• Galangin
• PURPUROGALLIN
• Quercetin
• HYDRINDANTIN
• Benzoylformic acid
• Benzoin
• Ninhydrin hydrate
• sodium phenylglyoxylate
• FISETIN HYDRATE
• 2-HYDROXY-1-(4-METHOXYPHENYL)-1-ETHANONE