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Pyridine-N-oxide

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Pyridine-N-oxide Basic information

Product Name:
Pyridine-N-oxide
Synonyms:
  • PYRIDINE-1-OXIDE
  • PYRIDINE-N-OXIDE
  • 1-oxidePyridine
  • Pyridine oxide
  • Pyridine N-oxide
  • pyridineoxide
  • Pyridin-N-oxid
  • Pyridine-N-Oxidee
CAS:
694-59-7
MF:
C5H5NO
MW:
95.1
EINECS:
211-774-6
Product Categories:
  • important intermediate
  • C5
  • Pyridine
  • Heterocyclic Building Blocks
  • Pyridines
Mol File:
694-59-7.mol
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Pyridine-N-oxide Chemical Properties

Melting point:
62-67 °C(lit.)
Boiling point:
270 °C(lit.)
Density 
1.1418 (rough estimate)
refractive index 
1.5939 (estimate)
Flash point:
143 °C
storage temp. 
2-8°C
form 
Crystalline Solid, Crystals, and/or Chunks
pka
0.79(at 24℃)
color 
White to brownish
Water Solubility 
soluble
Sensitive 
Hygroscopic
Merck 
14,7972
BRN 
105257
CAS DataBase Reference
694-59-7(CAS DataBase Reference)
NIST Chemistry Reference
Pyridine, 1-oxide(694-59-7)
EPA Substance Registry System
Pyridine, 1-oxide (694-59-7)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22-40-20/21/22
Safety Statements 
26-24/25-37/39-36/37/39-22
WGK Germany 
3
RTECS 
UT6410000
21
TSCA 
Yes
HS Code 
29333999

MSDS

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Pyridine-N-oxide Usage And Synthesis

Chemical Properties

White to light yellow solid

Uses

Pyridine N-Oxide is a useful reagent for the chemical industry, a mild reoxidant that transforms osmium-catalyzed oxidative cyclization. A catalytic agent.

Uses

Intermediate.

Definition

ChEBI: The pyridine N-oxide derived from the parent pyridine. It is a drug metabolite of the antihypertensive agent pinacidil.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 4, p. 828, 1963
Tetrahedron Letters, 12, p. 2807, 1971 DOI: 10.1016/S0040-4039(01)97047-9

General Description

Pyridine N-oxide axle with [2]rotaxanes was synthesized via an anion templated threading-followed-by-stoppering strategy.

Hazard

Probably flammable and toxic.

Purification Methods

Purify the N-oxide by crystallisation from Et2O and by vacuum sublimation. The picrolonate has m 182-184o. [Katritzky J Chem Soc 2407 1956, Beilstein 20 III/IV 2305, 20/5 V 217.]

Pyridine-N-oxide Preparation Products And Raw materials

Preparation Products

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