6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE Chemical Properties

Melting point:

235°C

Boiling point:

478.66°C (rough estimate)

Density 

1.2764 (rough estimate)

refractive index 

1.5855 (estimate)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

DMSO:84.5(Max Conc. mg/mL);246.08(Max Conc. mM)
Water:69.0(Max Conc. mg/mL);104.84(Max Conc. mM)

form 

Solid

color 

Pale Yellow to Light Yellow

CAS DataBase Reference

1837-57-6(CAS DataBase Reference)

EPA Substance Registry System

Rivanol (1837-57-6)

6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE Usage And Synthesis

Chemical Properties

Pale-yellow crystals. Slowly soluble in 15 parts water; soluble in 9 parts boiling water; soluble in 110 parts alcohol (22C). Solutions are yellow, fluorescent, and stable to boiling.

Originator

Rivanol,Sopharma

Uses

2-Ethoxy-6,9-diaminoacridine Lactate is used in treating purulent-necrotic wounds of hooves in cattle.

Uses

Bactericide, surgical antisepsis, preparation of pure γ-globulin.

Definition

ChEBI: Acrinol is an organic molecular entity.

Manufacturing Process

A mixture of 250 parts by volume of ethylene glycol, 50 parts by weight of 6- nitro-9-chloro-2-ethoxyacridine (obtained by reaction of 52 parts by weight of 30 nitro-4-ethoxy-diphenylamine-6-carboxylic acid with phosphorous oxychloride), 10 parts by weight of ammonium chloride, and 11 parts by weight of urea were heated to 170°C and stirred for 1 hour at 170°-175°C. Subsequently, the whole was cooled to 100°C, the reaction mixture was introduced into 1000 parts by volume of water, rendered acidic to Congo paper by means of hydrochloric acid and the 6-nitro-9-amino-2-ethoxyacridine precipitated was filtered off. By reduction iron according to Bechamp, 6,9- diamino-2-ethoxy-acridine hydrochloride was obtained with yield of 83% as the yellow needles. The base was prepared by adding an equivalent of NaOH. MP: 124°C.
In practice it is usually used as lactate.

Therapeutic Function

Antiseptic, Antibacterial

Safety Profile

Poison by subcutaneous, intraperitoneal, and intravenous routes. Experimental reproductive effects. An antiseptic. When heated to decomposition it emits toxic fumes of NOx.

6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE(1837-57-6)Related Product Information

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