ANTI-8-HYDROXYGUANOSINE
ANTI-8-HYDROXYGUANOSINE Basic information
- Product Name:
- ANTI-8-HYDROXYGUANOSINE
- Synonyms:
-
- ANTI-8-HYDROXYGUANOSINE
- ANTI-8-HYDROXYGUANOSINE GOAT PAB
- ANTI-8OHDG
- ANTI-8-OHG GOAT PAB
- ANTI-8-OXO-G GOAT PAB
- Anti-8OHG
- Anti-DNA/RNA Damage
- Monoclonal Anti-DNA/RNA Damage antibody produced in mouse
- MF:
- C10H13N5O6
- MW:
- 299.24012
- Mol File:
- Mol File
ANTI-8-HYDROXYGUANOSINE Chemical Properties
- storage temp.
- -20°C
- form
- buffered aqueous glycerol solution
ANTI-8-HYDROXYGUANOSINE Usage And Synthesis
General Description
DNA/RNA damage, also known as 8-hydroxyguanine (8-OHG), is a product of oxidized DNA or RNA.
Biochem/physiol Actions
8-hydroxyguanine (8-OHG) helps in determining the reactive oxygen species (ROS)-induced modification of a purine residue in DNA. It is a sensitive marker of oxidative DNA damage. Overexpression of the gene has been observed in diabetic patients, especially those with advanced microvascular complications. Thus, 8-OHG functions as a novel biomarker for identifying oxidative DNA damage in diabetic patients. Plasma level of 8-OHG elevates with the age, with cigarette smoking and during tumorigenesis. 8-OHG levels in urine is considered as a biomarker of the total systemic oxidative stress in vivo. Overexpression of 8-OHG has been observed in various neurodegenerative diseases such as Parkinson′s disease (PD) and multiple system atrophy (MSA).