DBCO-Acid
DBCO-Acid Basic information
- Product Name:
- DBCO-Acid
- Synonyms:
-
- DBCO-Acid
- Dibenzocyclooctyne-acid
- 11,12-Didehydro-gamma-oxodibenzo[b,f]azocine-5(6H)-butanoic Acid
- CAS_1353016-70-2
- DBCO acid 1
- 4-{2-azatricyclo[10.4.0.0?,?]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl}-4-oxobutanoic acid
- Azadibenzocyclooctyne acid
- DBCO-(CH2)2-COOH
- CAS:
- 1353016-70-2
- MF:
- C19H15NO3
- MW:
- 305.33
- Product Categories:
-
- ADC LINKER
- Mol File:
- 1353016-70-2.mol
DBCO-Acid Chemical Properties
- Melting point:
- 118-125 °C
- Boiling point:
- 622.0±55.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in dimethyl sulfoxide and dimethyl formamide.
- pka
- 4.47±0.17(Predicted)
- form
- Solid
- color
- Off-white to Gray
- InChI
- InChI=1S/C19H15NO3/c21-18(11-12-19(22)23)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13H2,(H,22,23)
- InChIKey
- NDLOVDOICXITOK-UHFFFAOYSA-N
- SMILES
- O=C(C([H])([H])C([H])([H])C(=O)O[H])N1C2=C([H])C([H])=C([H])C([H])=C2C#CC2=C([H])C([H])=C([H])C([H])=C2C1([H])[H]
DBCO-Acid Usage And Synthesis
Description
DBCO-Acid is a non-activated building block and adds minimal spacer to modified molecules. In the presence of activators such as EDC or HATU, this reagent can be used to derivatize amine-containing molecules through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.
Uses
DBCO-Acid is a reactant in the synthesis of high-generation polyester dendrimers. Also used in the preparation of modular, plasmin sensitive, clickable poly(ethylene glycol)-heparin-laminin microsphere systems for creating growth factor gradients in peripheral nerve regeneration.
General Description
Acid functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne click chemistry reactions. This azadibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.
DBCO-AcidSupplier
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DBCO-Acid(1353016-70-2)Related Product Information
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