Basic information Safety Supplier Related

DBCO-Acid

Basic information Safety Supplier Related

DBCO-Acid Basic information

Product Name:
DBCO-Acid
Synonyms:
  • DBCO-Acid
  • Dibenzocyclooctyne-acid
  • 11,12-Didehydro-gamma-oxodibenzo[b,f]azocine-5(6H)-butanoic Acid
  • CAS_1353016-70-2
  • DBCO acid 1
  • 4-{2-azatricyclo[10.4.0.0?,?]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl}-4-oxobutanoic acid
  • Azadibenzocyclooctyne acid
  • DBCO-(CH2)2-COOH
CAS:
1353016-70-2
MF:
C19H15NO3
MW:
305.33
Product Categories:
  • ADC LINKER
Mol File:
1353016-70-2.mol
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DBCO-Acid Chemical Properties

Melting point:
118-125 °C
Boiling point:
622.0±55.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in dimethyl sulfoxide and dimethyl formamide.
pka
4.47±0.17(Predicted)
form 
Solid
color 
Off-white to Gray
InChI
InChI=1S/C19H15NO3/c21-18(11-12-19(22)23)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13H2,(H,22,23)
InChIKey
NDLOVDOICXITOK-UHFFFAOYSA-N
SMILES
O=C(C([H])([H])C([H])([H])C(=O)O[H])N1C2=C([H])C([H])=C([H])C([H])=C2C#CC2=C([H])C([H])=C([H])C([H])=C2C1([H])[H]
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Safety Information

HS Code 
29339900
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DBCO-Acid Usage And Synthesis

Description

DBCO-Acid is a non-activated building block and adds minimal spacer to modified molecules. In the presence of activators such as EDC or HATU, this reagent can be used to derivatize amine-containing molecules through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

DBCO-Acid is a reactant in the synthesis of high-generation polyester dendrimers. Also used in the preparation of modular, plasmin sensitive, clickable poly(ethylene glycol)-heparin-laminin microsphere systems for creating growth factor gradients in peripheral nerve regeneration.

General Description

Acid functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne click chemistry reactions. This azadibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

DBCO-AcidSupplier

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