DBCO-Acid Chemical Properties

Melting point:

118-125 °C

Boiling point:

622.0±55.0 °C(Predicted)

Density 

1.34±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in dimethyl sulfoxide and dimethyl formamide.

form 

Solid

pka

4.47±0.17(Predicted)

color 

Off-white to Gray

Safety Information

HS Code 

29339900

DBCO-Acid Usage And Synthesis

Description

DBCO-Acid is a non-activated building block and adds minimal spacer to modified molecules. In the presence of activators such as EDC or HATU, this reagent can be used to derivatize amine-containing molecules through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

DBCO-Acid is a reactant in the synthesis of high-generation polyester dendrimers. Also used in the preparation of modular, plasmin sensitive, clickable poly(ethylene glycol)-heparin-laminin microsphere systems for creating growth factor gradients in peripheral nerve regeneration.

General Description

Acid functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne click chemistry reactions. This azadibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

DBCO-Acid(1353016-70-2)Related Product Information

• Dbco-Amine TFA
• Cy5 DBCO
• Azadibenzocyclooctyne-Biotin conjugate
• Oleic-DBCO
• DBCO-C-PEG1
• DBCO-C6-acid
• BDP FL DBCO
• DBCO-(CH2)2-NH2-CO-(CH2)2COOH
• DBCO-amine
• DBCO-NHS Ester
• DBCO-(CH2)2-NH2-CO-(CH2)3COOH
• DBCO-(CH2)3-Acid
• Hydroxy-PEG2-CH2CO2H
• 3-[2-(2-Hydroxyethoxy)ethoxy]propanoic acid
• disulfo-ICG-carboxylic acid(tri-sulfo-cy7.5 COOH)
• Dibenzothiophene
• DIBENZAZEPINE
• Phthalan