Tetrazine-PEG4-maleimide Chemical Properties

Density 

1.286±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO, DCM, DMF

pka

15.01±0.46(Predicted)

form 

Solid

color 

Purple to purplish red

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/38

Safety Statements 

26

Tetrazine-PEG4-maleimide Usage And Synthesis

Description

Methyltetrazine-PEG4-Maleimide is a click chemistry Maleimide linker. The maleimide group specifically and efficiently reacts with thiols to form thioether bond. This reagent can be used to efficieintly incorporate a tetrazine moiety with TCO-attached compound or macromolecule.

Uses

Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methyltetrazine-PEG4-maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Tetrazine-PEG4-maleimide(1802908-02-6)Related Product Information

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• Tetrazine-PEG5-NHS ester
• Tetrazine-PEG5-COOH
• N-[2-[2-[2-[2-(Aminooxy)ethoxy]ethoxy]ethoxy]ethoxy]-4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzeneacetamide
• Me-Tet-PEG4-NH2
• Methyltetrazine-PEG4-Azide
• Desthiobiotin-PEG4-Alkyne
• Methyltetrazine-PEG4-Amine
• Dde Biotin-PEG4-Alkyne
• Methyltetrazine-PEG5-Alkyne
• Dde Biotin-PEG4-Azide
• Bis-sulfone-PEG3-Azide
• Methyltetrazine-PEG4-NHS Ester