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ChemicalBook >  Product Catalog >  Analytical Chemistry >  Standard >  Pharmaceutical Impurity Reference Standards >  Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate

Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate

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Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate Basic information

Product Name:
Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate
Synonyms:
  • LCZ696-9
  • LCZ696(valsartan + sacubitril) impurity 9
  • ethyl(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoate
  • Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate
  • LCZ700
  • (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoate
  • LCZ-696 Impurity 4
  • LCZ-696-006-RS
CAS:
1038924-97-8
MF:
C24H27NO4
MW:
393.48
Product Categories:
  • LCZ696
Mol File:
1038924-97-8.mol
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Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate Chemical Properties

Boiling point:
581.3±50.0 °C(Predicted)
Density 
1.166±0.06 g/cm3(Predicted)
solubility 
Chloroform (Sparingly), Ethyl Acetate (Slightly)
form 
Solid
pka
-1.52±0.20(Predicted)
color 
White to Off-White Waxy
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Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate Usage And Synthesis

Uses

Sacubitril Impurity 2 is an impurity of Sacubitril (S080895) which is an antihypertensive drug used in combination with valsartan.

Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoateSupplier

Adamas Reagent, Ltd.
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Beijing Comparison Pharmaceutical Technology Co., Ltd
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