4-Fluorobenzaldehyde Chemical Properties

Melting point:

-10 °C (lit.)

Boiling point:

181 °C/758 mmHg (lit.)

Density 

1.157 g/mL at 25 °C (lit.)

vapor pressure 

19 hPa (70 °C)

refractive index 

n20/D 1.521(lit.)

Flash point:

134 °F

storage temp. 

Store below +30°C.

solubility 

Chloroform, Methanol

form 

Liquid

color 

Clear colorless to yellow

Specific Gravity

1.157

Water Solubility 

IMMISCIBLE

Sensitive 

Air Sensitive

BRN 

385857

Stability:

Air Sensitive

InChIKey

UOQXIWFBQSVDPP-UHFFFAOYSA-N

CAS DataBase Reference

459-57-4(CAS DataBase Reference)

NIST Chemistry Reference

Benzaldehyde, 4-fluoro-(459-57-4)

EPA Substance Registry System

Benzaldehyde, 4-fluoro- (459-57-4)

Safety Information

Hazard Codes 

Xi,F

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39-36/37/39-27

RIDADR 

UN 1989 3/PG 3

WGK Germany 

2

F 

9-23

Hazard Note 

Flammable

TSCA 

T

HazardClass 

3.2

PackingGroup 

III

HS Code 

29130000

MSDS

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4-Fluorobenzaldehyde Usage And Synthesis

Chemical Properties

Clear colorless to yellow liquid

Uses

Usually used in the preparation of pyrazolopyridine UR-13756.

Uses

4-Fluorobenzaldehyde is used in the preparation of pyrazolopyridine derivative, which finds application as mitogen-activated protein kinase (MAPK) inhibitor. It also serves as a synthetic intermediate in the preparation of pharmaceutical compounds.

Uses

4-Fluorobenzaldehyde is a fluorinated benzaldehyde with inhibitory activity of mushroom tyrosinase. 4-Fluorobenzaldehyde is commonly used as a synthetic intermediate in the preparation of pharmaceutic al compounds.

Synthesis

4-Fluorobenzaldehyde is produced by a commercially feasible process. The process comprises heating a mixture of fluorobenzene and a strong Lewis acid with dissolved hydrogen halide in an atmosphere of carbon monoxide at about 45 to about 100° C. and at a total pressure of about 150 psig up to the maximum pressure rating of the reactor. Formed is a reaction mass containing a Lewis acid complex of 4-fluorobenzaldehyde and at least a halobis(fluorophenyl)methane by-product. The complex is broken by quenching the reaction mass with a Lewis acid-solvating liquid to liberate 4-fluorobenzaldehyde. By-product halobis(fluorophenyl)methane is converted to di(fluorophenyl)methanol to avoid potential corrosion problems and formation of light-sensitive color bodies in the recovered 4-fluorobenzaldehyde.

4-Fluorobenzaldehyde(459-57-4)Related Product Information

• 4-Fluorobenzoic acid
• Florfenicol
• 3-Fluorobenzaldehyde
• Pentafluorobenzaldehyde
• 4-Bromofluorobenzene
• 2,6-Difluorobenzaldehyde
• Ethyl 4-fluorobenzoate
• Transfluthrin
• 1,2-Difluorobenzene
• 4-Fluoroanisole
• 4-Fluorobenzoyl chloride
• 4-Fluorothiophenol
• 4-Fluoronitrobenzene
• 4-Fluorobenzyl alcohol
• 4-Methylbenzyl chloride
• 4-Chlorobenzaldehyde
• p-Fluorotoluene
• 4-Fluoromandelic acid