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Nonaethylene glycol

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Nonaethylene glycol Basic information

Product Name:
Nonaethylene glycol
Synonyms:
  • NONAETHYLENE GLYCOL
  • 3,6,9,12,15,18,21,24-octaoxahexacosane-1,26-diol
  • peg-9,polyoxyethylene(9),polyethyleneglycol450
  • Nonaethylene glyco
  • 2,2'-[1,2-Ethanediylbis[oxy(2,1-ethanediyl)oxy(2,1-ethanediyl)oxy(2,1-ethanediyl)oxy]]bis(ethanol)
  • HO-PEG9-OH
  • PEG-9
  • 2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
CAS:
3386-18-3
MF:
C18H38O10
MW:
414.49
EINECS:
222-206-1
Product Categories:
  • Ethylene Glycols
  • Ethylene Glycols & Monofunctional Ethylene Glycols
  • Linker
  • peg
  • SiChem
Mol File:
3386-18-3.mol
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Nonaethylene glycol Chemical Properties

Melting point:
24.0-25.2 °C
Boiling point:
190 °C(Press: 0.01 Torr)
Density 
1.115±0.06 g/cm3(Predicted)
refractive index 
1.46
Flash point:
26 °C
storage temp. 
2-8°C
form 
powder to lump
pka
14.06±0.10(Predicted)
color 
White to Almost white
InChI
InChI=1S/C18H38O10/c19-1-3-21-5-7-23-9-11-25-13-15-27-17-18-28-16-14-26-12-10-24-8-6-22-4-2-20/h19-20H,1-18H2
InChIKey
YZUUTMGDONTGTN-UHFFFAOYSA-N
SMILES
C(O)COCCOCCOCCOCCOCCOCCOCCOCCO
EPA Substance Registry System
Nonaethylene glycol (3386-18-3)
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Safety Information

RTECS 
RA5400000
HS Code 
2905.39.9000
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Nonaethylene glycol Usage And Synthesis

Description

Nonaethylene glycol is a polymer consisting of ethylene glycol repeating units and terminal hydroxyl groups. The ethylene glycol units have high water solubility properties. The hydroxyl groups can react in order to further derivatize the compound.

Uses

HO-PEG9-OH is used as a reactant in the selective inhibition of human brain tumor cells through quantum-dot-based siRNA delivery.

Definition

ChEBI: Nonaethylene glycol is a poly(ethylene glycol).

Synthesis

Nonaethylene glycol could be synthesized by reacting the monosodium salt of triethylene glycol with the ditosylate of triethylene glycol [2] in solution in tetrahydrofuran. A small amount of less pure pentadecaethylene glycol was also isolated from the preparation[1].

References

[1] H. H. Teo, C. Booth, R. H. Mobbs. “Preparation of ethylene glycol oligomers—II.” European Polymer Journal 18 1 (1982): 541–544.

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