Prolactin Releasing Peptide (12-31), human
Prolactin Releasing Peptide (12-31), human Basic information
- Product Name:
- Prolactin Releasing Peptide (12-31), human
- Synonyms:
-
- PRRP31
- PRRP31 (HUMAN)
- Prolactin-releasing peptide human, ≥97% (HPLC)
- H-THR-PRO-ASP-ILE-ASN-PRO-ALA-TRP-TYR-ALA-SER-ARG-GLY-ILE-ARG-PRO-VAL-GLY-ARG-PHE-NH2
- H-SER-ARG-THR-HIS-ARG-HIS-SER-MET-GLU-ILE-ARG-THR-PRO-ASP-ILE-ASN-PRO-ALA-TRP-TYR-ALA-SER-ARG-GLY-ILE-ARG-PRO-VAL-GLY-ARG-PHE-NH2
- Prolactin-releasing Peptide Fragment 12-31 human
- Prolactin-releasing Peptide Fragment 12-31 rat
- PrRP20 (huMan), Preprolactin (34-53) (huMan)
- CAS:
- 235433-36-0
- MF:
- C104H158N32O26
- MW:
- 2272.57
- Product Categories:
-
- peptide
- Mol File:
- 235433-36-0.mol
Prolactin Releasing Peptide (12-31), human Chemical Properties
- Density
- 1.50±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- form
- Solid
- color
- White to off-white
- Sequence
- Thr-Pro-Asp-Ile-Asn-Pro-Ala-Trp-Tyr-Ala-Ser-Arg-Gly-Ile-Arg-Pro-Val-Gly-Arg-Phe-NH2
MSDS
- Language:English Provider:SigmaAldrich
Prolactin Releasing Peptide (12-31), human Usage And Synthesis
Uses
Prolactin Releasing Peptide (12-31), human is a fragment of the prolactin releasing peptide (PrRP). Prolactin Releasing Peptide (1-31), human is a high affinity GPR10 ligand that cause the release of the prolactin.
in vivo
Following intracerebroventricular injection of Prolactin Releasing Peptide (1-31), human 5 nM there is a highly significant simulation of plasma LH that began at 10 minutes and is maintained over the course of the experiment. Plasma FSH increased at 20 minutes following ICV injection. Total plasma testosterone increased at 60 minutes post injection[3].
References
[1] Roland BL, et al. Anatomical distribution of prolactin-releasing peptide and its receptor suggests additional functions in the central nervous system and periphery. Endocrinology. 1999 Dec;140(12):5736-45. DOI:10.1210/endo.140.12.7211
[2] Langmead CJ, et al. Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor. Br J Pharmacol. 2000 Oct;131(4):683-8. DOI:10.1038/sj.bjp.0703617
[3] Seal LJ, et al. Prolactin releasing peptide (PrRP) stimulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) via a hypothalamic mechanism in male rats. Endocrinology. 2000 May;141(5):1909-12. DOI:10.1210/endo.141.5.7528
Prolactin Releasing Peptide (12-31), humanSupplier
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Prolactin Releasing Peptide (12-31), human(235433-36-0)Related Product Information
- Prolactin-Releasing Peptide (12-31), rat
- PROLACTIN,HUMAN,RECOMBINANT
- Prolactin Releasing Peptide (1-31), HumanPrRP-31
- Prolactin, Mouse, Recombinant
- Prolactin, rat recombinant
- Prokineticin-2, Human, Recombinant
- H-THR-PRO-ASP-ILE-ASN-PRO-ALA-TRP-TYR-ALA-GLY-ARG-GLY-ILE-ARG-PRO-VAL-GLY-ARG-PHE-NH2
- H-SER-ARG-ALA-HIS-GLN-HIS-SER-MET-GLU-ILE-ARG-THR-PRO-ASP-ILE-ASN-PRO-ALA-TRP-TYR-ALA-GLY-ARG-GLY-ILE-ARG-PRO-VAL-GLY-ARG-PHE-NH2
- Prolactin-Releasing Peptide (1-31) (human)
- H-SER-ARG-ALA-HIS-GLN-HIS-SER-MET-GLU-THR-ARG-THR-PRO-ASP-ILE-ASN-PRO-ALA-TRP-TYR-THR-GLY-ARG-GLY-ILE-ARG-PRO-VAL-GLY-ARG-PHE-NH2
- Prolactin Releasing Peptide (12-31), human