BETA-HYDROXYISOVALERYLSHIKONIN Chemical Properties

Melting point:

90-92 °C

Boiling point:

616.9±55.0 °C(Predicted)

Density 

1.312±0.06 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

Soluble in DMSO

pka

7.08±0.20(Predicted)

form 

Solid

color 

Brown to black

LogP

2.424 (est)

BETA-HYDROXYISOVALERYLSHIKONIN Usage And Synthesis

Uses

Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells[1].

References

[1] Hashimoto S, et al. Beta-hydroxyisovalerylshikonin is a novel and potent inhibitor of protein tyrosine kinases. Jpn J Cancer Res. 2002 Aug;93(8):944-51. DOI:10.1111/j.1349-7006.2002.tb01341.x

BETA-HYDROXYISOVALERYLSHIKONIN(7415-78-3)Related Product Information

• ISOBUTYRYLSHIKONIN
• Alkannin
• (BETA,BETA-DIMETHYLACRYL)SHIKONIN
• 3-(Acetyloxy)-3-methylbutanoic acid (1S)-1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxo-2-naphthalenyl)-4-methyl-3-pentenyl ester
• BETA, BETA-DIMETHYLACRYLALKANNIN
• Dihydroechinofuran
• PLUMBAGIN
• BETA-HYDROXYISOVALERYLSHIKONIN
• Shikalkin
• Geroquinol
• ACETYLSHIKONIN
• DEOXYSHIKONIN
• 5,8-Dihydroxy-1,4-naphthoquinone
• Shikonin
• ISOVALERYLSHIKONIN