MSI-1436
MSI-1436 Basic information
- Product Name:
- MSI-1436
- Synonyms:
-
- MSI-1436
- Trodusquemine
- TRODUSQUEMINE;AMINOSTEROL-1436;MSI1436
- Cholestane-7,24-diol, 3-[[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]amino]-, 24-(hydrogen sulfate), (3β,5α,7α,24R)-
- Trodusquemine (MSI-1436)
- MSI-1436 USP/EP/BP
- MSI-1436(Trodusquemine
- MSI 1436,MSI1436
- CAS:
- 186139-09-3
- MF:
- C37H72N4O5S
- MW:
- 685.07
- EINECS:
- 202-303-5
- Mol File:
- 186139-09-3.mol
MSI-1436 Chemical Properties
- Density
- 1.12±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- Soluble in DMSO
- pka
- -3.49±0.18(Predicted)
- form
- Solid
- color
- White to yellow
MSI-1436 Usage And Synthesis
Uses
Treatment of medically significant obesity.
Uses
Trodusquemine is a specific protein tyrosine phosphatase 1B (PTP1B) inhibitor.
Definition
ChEBI: Trodusquemine is a bile acid.
in vivo
MSI-1436 (10 mg/kg, i.p.) causes obesity-dependent body weight, reduces total body fat content and adipocyte size and lipid content of white adipose tissue of mice. MSI-1436 treatment significantly reduces plasma insulin levels. MSI-1436 (10 mg/kg, i.p.) increases phosphorylation of STAT-3 2.7-fold and, in conjunction with 100 U/kg insulin, p-IRβ increases threefold over insulin alone-treated rats[1]. MSI-1436 (Trodusquemine) exhibits anxiolytic effect through a restoration of endocannabinoid (eCB) signaling within the amygdala[2]. MSI-1436 (5 mg/kg, i.p.) has an anti-diabetic effect on diabetic mice, and is sufficient to suppress food intake and cause weight loss in CD1 mice[3].
MSI-1436Supplier
- Tel
- 021-58950125
- info@chemexpress.com
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
- Tel
- 021-65675885 18964387627
- info@efebio.com
- Tel
- +1-800-259-7612
- info@musechem.com
- Tel
- meitaochem@126.com
- meitaochem@126.com