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DIPHENOXYLATE HYDROCHLORIDE

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DIPHENOXYLATE HYDROCHLORIDE Basic information

Product Name:
DIPHENOXYLATE HYDROCHLORIDE
Synonyms:
  • Diphenoxylate for system suitability
  • Diphenoxylate hydrochloride solution
  • 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecoticacidethylesterhydrochl
  • ethyl1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotatemonohydrochloride
  • isonipecoticacid,1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-,ethylester,hydro
  • r1132
  • Diphenoxylate HCL (Subj To Narcotic Permit)
  • DIPHENOXYLATE HCL
CAS:
3810-80-8
MF:
C30H33ClN2O2
MW:
489.05
EINECS:
223-287-6
Product Categories:
  • Amines
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
3810-80-8.mol
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DIPHENOXYLATE HYDROCHLORIDE Chemical Properties

Melting point:
220.5-222°
storage temp. 
-20°C
solubility 
Very slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in ethanol (96 per cent).
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Safety Information

RIDADR 
1544
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2933330000
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DIPHENOXYLATE HYDROCHLORIDE Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder.

Originator

Lomotil,Searle,US,1960

Uses

Antiperistaltic; antidiarrheal. Controlled substance (opiate).

Definition

ChEBI: The hydrochloride salt of diphenoxylate.

Manufacturing Process

A mixture of 23 parts of the ethyl ester of 4-phenylisonipecotic acid and 15 parts of 2,2-diphenyl-4-
omobutyronitrile in 19 parts of xylene is heated for 24 hours at 100-120°C and then cooled and filtered to remove the precipitate of the hydro
omide of the ethyl ester of 4-phenylisonipecotic acid. The filtrate is then extracted with dilute hydrochloric acid and the extract is rendered alkaline by addition of concentrated aqueous potassium hydroxide and extracted with ether. This ether extract is treated with gaseous hydrogen chloride. The resulting precipitate is collected on a filter. The hydrochloride of the ethyl ester of 2,2-diphenyl-4-(4'-carboxy-4'-phenyl-1'- piperidino)butyronitrile thus obtained melts at about 220.5-222°C. See meperidine hydrochloride for synthesis of 4-phenyl-isonipecotic acid ethyl ester.

Therapeutic Function

Antidiarrheal

Veterinary Drugs and Treatments

Diphenoxylate is an opiate in combination with atropine in antidiarrheal products used primarily in dogs; it also has antitussive properties. Use in cats is controversial and many clinicians do not recommend its use in this species.

DIPHENOXYLATE HYDROCHLORIDESupplier

Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
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shchemsky@sina.com
Wuhan Henruixintai Biological Co., Ltd.
Email
360034463@qq.com
AFINE CHEMICALS LIMITED
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008657185134551
Email
info@afinechem.com
career henan chemical co
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0086-371-86658258
Email
factory@coreychem.com
Energy Chemical
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021-58432009-
Email
marketing@energy-chemical.com