Acid-PEG6-mono-methyl ester Chemical Properties

Boiling point:

503.7±50.0 °C(Predicted)

Density 

1.147±0.06 g/cm3(Predicted)

solubility 

Soluble in Water, DMSO, DCM, DMF

pka

4.28±0.10(Predicted)

Acid-PEG6-mono-methyl ester Usage And Synthesis

Description

Acid-PEG6-mono-methyl ester is a PEG linker containing a terminal carboxylic acid and a methyl ester group. The carboxylic acid can react with primary amine groups in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic PEG linkers increase the water solubility of a compound in aqueous media. The water solubility properties of the PEG chain are enhanced with longer PEG chains.

Uses

Acid-PEG6-mono-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Acid-PEG6-mono-methyl ester(1807512-38-4)Related Product Information

• Acid-PEG7-NHS ester
• Acid-PEG3-NHS ester
• Acid-PEG3-mono-methyl ester
• Acid-PEG25-NHS ester
• Acid-PEG4-mono-methyl ester
• Acid-PEG5-mono-methyl ester
• Acid-PEG4-t-butyl ester
• Acid-PEG3-t-butyl ester
• Acid-PEG9-NHS ester
• Acid-PEG13-NHS ester