Ald--Ph-PEG2-acid Chemical Properties

Boiling point:

568.4±50.0 °C(Predicted)

Density 

1.248±0.06 g/cm3(Predicted)

solubility 

Soluble in Water, DMSO, DMF

pka

4.27±0.10(Predicted)

Ald--Ph-PEG2-acid Usage And Synthesis

Description

Ald-Ph-PEG2-acid is a small PEG reagent with a benzaldehyde moiety and a terminal carboxylic acid group. The benzaldehyde group is reactive with hydrazide and aminooxy moiety. The terminal carboxylic acid can undergo reactions with primary amines in the presence of activators such as EDC or HATU to form a stable amide bond.

Uses

Ald-Ph-amido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

Ald--Ph-PEG2-acid(1807534-84-4)Related Product Information

• Ald--Ph-PEG3-amine
• Ald-Ph-PEG4-t-butyl ester
• Acid-PEG4-t-butyl ester
• Ald-Ph-PEG4-acid
• Ald-Ph-PEG2-t-butyl ester
• Ald-PEG4-t-butyl ester
• Acid-PEG3-t-butyl ester
• Acid-PEG6-t-butyl ester
• Ald-PEG5-t-butyl ester
• Acid-PEG5-t-butyl ester
• Ald-Ph-PEG2-amine
• m-PEG4-benzaldehyde
• Ald--Ph-PEG2-NHS
• Ald-PEG4-NHS ester
• Ald-Ph-PEG6-t-butyl ester
• Ald-Ph-PEG3-Azide
• m-PEG4-CH2-aldehyde
• Ald-PEG5-Azide