Amino-PEG36-acid Chemical Properties

Boiling point:

1181.6±65.0 °C(Predicted)

Density 

1.121±0.06 g/cm3(Predicted)

storage temp. 

-20°C

form 

solid or viscous liquid

pka

4.28±0.10(Predicted)

InChIKey

QKMSNDXWGWBERW-UHFFFAOYSA-N

SMILES

C(COCCOCCOCCC(=O)O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN

Safety Information

HS Code 

2918999090

Amino-PEG36-acid Usage And Synthesis

Appearance

Amino-PEG24-acid is in solid powder form.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Description

Amino-PEG24-acid is a PEG derivative containing an amino group with a terminal carboxylic acid. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Uses

Amino-PEG36-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

General Description

Amino-dPEG^?₁₂-acid is a novel amino acid that can be manipulated, modified, and used like most other amino acids. The single molecular weight dPEG^? spacer arms between the terminal amine and the terminal carboxylic acid are of exact length (46.5 ?), allowing for precise spatial control, and they are hydrophilic and non-immunogenic, imparting greater water solubility and hydrodynamic volume to target molecules.

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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