Azido-PEG4-beta-D-glucose Chemical Properties

solubility 

Soluble in Water, DMSO, DMF

form 

Oil

color 

Light brown to brown

Azido-PEG4-beta-D-glucose Usage And Synthesis

Description

Azido-PEG4-beta-D-glucose is a PEG linker containing one azide group and one D-glucose group. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. D-glucose increases solubility in aqueous media and increases the selectivity of the PEGylation reaction.

Uses

Azido-PEG4-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-beta-D-glucose is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azido-PEG4-beta-D-glucose(1609083-15-9)Related Product Information

• HEPTAKIS-6-AZIDO-6-DEOXY-BETA-CYCLODEXTRIN, 1:1 DMF COMPLEX, 95
• Methyl 6-azido-6-deoxy-alpha-D-glucopyranoside
• 2-AZIDOETHYL-BETA-D-FRUCTOPYRANOSIDE
• Octakis-(6-azido-6-deoxy)-γ-cyclodextrin
• beta-Gal-PEG3-Azide
• Ald-PEG5-Azide
• Azido-PEG1-methyl ester
• Azido-PEG1-CH2CO2-NHS
• Azido-PEG1-methylamine
• Azido-PEG3-methyl ester
• Azido-PEG7-acid
• Azido-PEG5-PFP ester
• Azide-PEG7-Tos
• Azidoethyl-SS-ethylamine