Basic information Safety Supplier Related

Azido-PEG5-acid

Basic information Safety Supplier Related

Azido-PEG5-acid Basic information

Product Name:
Azido-PEG5-acid
Synonyms:
  • Azido-PEG5-propionic acid
  • N3-PEG5-COOH
  • Azido-PEG5-acid,N3-PEG5-COOH
  • 1-azido-3,6,9,12,15-pentaoxaoctadecan-18-oic acid
  • N3-PEG5-CH2CH2COOH/Propanoic acid, 3-[(14-azido-3,6,9,12-tetraoxatetradec-1-yl)oxy]-
  • Azido-PEG5-CH2CH2COOH
CAS:
1425973-16-5
MF:
C13H25N3O7
MW:
335.36
Product Categories:
  • peg
Mol File:
1425973-16-5.mol
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Azido-PEG5-acid Chemical Properties

solubility 
Soluble in Water
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Azido-PEG5-acid Usage And Synthesis

Description

Azido-PEG5-acid is a water soluble PEG linker. Azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry.. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Biological Activity

Azido-PEG3-acid is a PROTAC linker belonging to the PEG class. It can be used to synthesize PROTAC molecules. Also Azido-PEG3-acid is a non-cleavable ADC linker containing 5-unit PEG that can be used to synthesize antibody drug conjugates (ADCs).

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

PEGs

Non-cleavable

Azido-PEG5-acidSupplier

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Azido-PEG5-acid(1425973-16-5)Related Product Information