7-Nitroindazole Chemical Properties

Melting point:

185-186°C

Boiling point:

290.19°C (rough estimate)

Density 

1.4141 (rough estimate)

refractive index 

1.5500 (estimate)

storage temp. 

-20°C

solubility 

Soluble to 100 mM in DMSO and to 20 mM in ethanol

pka

10.03±0.40(Predicted)

form 

powder to crystal

color 

Light yellow to Brown

Water Solubility 

slightly soluble

BRN 

6809

InChI

InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9)

InChIKey

PQCAUHUKTBHUSA-UHFFFAOYSA-N

SMILES

N1C2=C(C=CC=C2[N+]([O-])=O)C=N1

CAS DataBase Reference

2942-42-9(CAS DataBase Reference)

NIST Chemistry Reference

7-Nitroindazole(2942-42-9)

Safety Information

Hazard Codes 

T

Risk Statements 

60-40

Safety Statements 

53-22-36/37/39-45

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

NK7962200

HazardClass 

IRRITANT

PackingGroup 

Ⅲ

HS Code 

29339900

MSDS

• Language:English Provider:7-Nitro-1H-indazole
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

7-Nitroindazole Usage And Synthesis

Description

7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro. However, it shows good anti-nociceptive effects in vivo without affecting blood pressure via inhibition of eNOS. The IC₅₀ values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.71, 0.78, and 5.8 μM, respectively.

Chemical Properties

yellow powder or Yellow orange solid soluble in DMSO.

Uses

7-nitroindazole is a specific inhibitor of neural nitric oxide synthase (nNOS), an enzyme that converts arginine to citrulline and nitric oxide (NO) in neuronal tissue. NO is a key player in the hippocampal long-term potentiation (LTP) and in general cell signaling.

Definition

7-Nitroindazole is a heterocyclic small molecule containing an indazole ring that has been nitrated at the 7 position. It is a potent, selective brain inhibitor of mouse cerebellar Nitric Oxide Synthase, a hemoprotein enzyme that, in neuronal tissue, converts arginine to citrulline and nitric oxide (NO).

Biological Activity

Sodium salt of the non-selective NOS inhibitor 7-nitroindazole (7-Nitroindazole).

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