Bis-PEG6-NHS ester
Bis-PEG6-NHS ester Basic information
- Product Name:
- Bis-PEG6-NHS ester
- Synonyms:
-
- BIS-PEG6-NHS
- 4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1,22-bis(2,5-dioxo-1-pyrrolidinyl) ester
- Bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16,19-hexaoxadocosanedioate
- Di-NHS Ester-PEG6
- CAS:
- 1526718-98-8
- MF:
- C24H36N2O14
- MW:
- 576.55
- Mol File:
- 1526718-98-8.mol
Bis-PEG6-NHS ester Chemical Properties
- solubility
- Soluble in DMSO, DCM
Bis-PEG6-NHS ester Usage And Synthesis
Description
Bis-PEG6-NHS ester is a PEG linker containing two NHS ester groups. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
Biological Activity
Bis-PEG6-NHS ester is a PROTAC bridge and belongs to the PEG class. It can be used to synthesize a range of PROTAC molecules. Also Bis-PEG6-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
| Alkyl/ether
|
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