Br-PEG1-COOtBu Chemical Properties

Boiling point:

285.0±15.0 °C(Predicted)

Density 

1.264±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in DCM, Hexane

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C9H17BrO3/c1-9(2,3)13-8(11)4-6-12-7-5-10/h4-7H2,1-3H3

InChIKey

KRGOEVTUVNSLIG-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)CCOCCBr

Br-PEG1-COOtBu Usage And Synthesis

Description

Bromo-PEG1-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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