Lipoamido-PEG4-acid CAS#: 1314378-10-3

Lipoamido-PEG4-acid Basic information

Product Name:

Lipoamido-PEG4-acid

Synonyms:

Lipoamido-PEG4-acid
LA-PEG4-COOH
LIPOAMIDO-PEG4-COOH
Lipoamido-PEG4-CH2CH2COOH
4,7,10,13-Tetraoxa-16-azaheneicosanoic acid, 21-(1,2-dithiolan-3-yl)-17-oxo-
Lipoamido-PEG-acid
Lipoamido-PEG4-CH2CH2COOH/4,7,10,13-Tetraoxa-16-azaheneicosanoic acid, 21-(1,2-dithiolan-3-yl)-17-oxo

CAS:

1314378-10-3

MF:

C19H35NO7S2

MW:

453.61

Product Categories:

peg

Mol File:

1314378-10-3.mol

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Lipoamido-PEG4-acid Usage And Synthesis

Description

Lipoamido-PEG4-acid contains a lipoic acid group and a terminal carboxylic acid. Lipoic acid contains two sulfur atoms (at C6 and C8) connected by a disulfide bond and is thus considered to be oxidized although either sulfur atom can exist in higher oxidation states. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG linker increases the water solubility of the compound.

Uses

Lipoamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Lipoamido-PEG4-acidSupplier

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