Basic information Safety Supplier Related

Propargyl-PEG5-amine

Basic information Safety Supplier Related

Propargyl-PEG5-amine Basic information

Product Name:
Propargyl-PEG5-amine
Synonyms:
  • Propargyl-PEG5-amine
  • HC≡C-CH2-PEG6-NH2
  • Alkyne-PEG5-NH2
  • PROPARGYL-PEG5-NH2
  • 3,6,9,12,15-Pentaoxaoctadec-17-yn-1-amine
  • Propargyl-PEG5-NH2/3,6,9,12,15-Pentaoxaoctadec-17-yn-1-amine
  • 2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethanamine
CAS:
1589522-46-2
MF:
C13H25NO5
MW:
275.34
Product Categories:
  • PROTAC Linker
  • PROTAC
  • peg
Mol File:
1589522-46-2.mol
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Propargyl-PEG5-amine Chemical Properties

Boiling point:
360.4±37.0 °C(Predicted)
Density 
1.049±0.06 g/cm3(Predicted)
solubility 
DMSO : 100 mg/mL (363.19 mM; Need ultrasonic)
pka
8.74±0.10(Predicted)
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Propargyl-PEG5-amine Usage And Synthesis

Description

Propargyl-PEG5-amine is a propargyl linker that is commonly used as a Click Chemistry reagent for copper-catalyzed reactions with azides. The amine moiety reacts with carboxylic acids, activated NHS esters and other carbonyl compounds. The PEG spacer helps improve the water solubility of the molecule in aqueous media.

Biological Activity

Propargyl-PEG5-amine is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

Non-cleavable

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PEGs

Propargyl-PEG5-amineSupplier

PharmaBlock Sciences (Nanjing),Inc.
Tel
400-0255188 4000255188
Email
sales@pharmablock.com
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Email
han_yajun@dctc.daicel.com
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Tongling HengYou Biotechnology Co., Ltd.
Tel
021-50426030 13856289449
Email
2630597085@qq.com
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
Tel
0431-80514535 19917294565
Email
et@chemextension.com
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Propargyl-PEG5-amine(1589522-46-2)Related Product Information